Protein Info for BBR_RS18725 in Bifidobacterium breve UCC2003

Annotation: ribonuclease HI

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 PF00075: RNase_H" amino acids 3 to 150 (148 residues), 104.7 bits, see alignment E=2.4e-34

Best Hits

Predicted SEED Role

"Ribonuclease HI (EC 3.1.26.4)" in subsystem Ribonuclease H (EC 3.1.26.4)

Isozymes

Compare fitness of predicted isozymes for: 3.1.26.4

Use Curated BLAST to search for 3.1.26.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (365 amino acids)

>BBR_RS18725 ribonuclease HI (Bifidobacterium breve UCC2003)
MTIVVSTDGSALGNPNGPMGWAWADHDKNAGGTAGHEHDDHGYDAGGATNGTNQIGELCA
VLEALRAHPGSEPLLIESDSQYAINCSTTWVKGWKKNGWKNSQKKPVKNVELVKAIDREI
SQRPGPVNFKWVKGHAGNEGNELVDELARTYAGDCRSGARDGYLPIEGWQSLLGSEYARG
TDVPPDVQLVLDGKADATSLRKPVAADPNTAPGGTPHQVKPSLEELLTEPEGVPDWGDDT
PTAEAPTITIDEKSVSNAATNDTPRNATSSPNAAQSPAAEQTPAASTSTATAAPTPTQPA
QPAATTPTATPSGLTVSGALRFSPAPKTSPYFNGQPMPIRGSIEVQGYVDGDGNLVITNA
PFTRH