Protein Info for BBR_RS18225 in Bifidobacterium breve UCC2003

Annotation: lactaldehyde reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02638: lactaldehyde reductase
  • amino acids 3 to 379 (377 residues), 524.5 bits, E=6.7e-162
• PF00465: Fe-ADH
  • amino acids 10 to 375 (366 residues), 370.5 bits, E=8.1e-115
• PF13685: Fe-ADH_2
  • amino acids 13 to 277 (265 residues), 57.4 bits, E=2e-19

Best Hits

Swiss-Prot: 60% identical to FUCO_ECO57: Lactaldehyde reductase (fucO) from Escherichia coli O157:H7

KEGG orthology group: K00048, lactaldehyde reductase [EC: 1.1.1.77] (inferred from 99% identity to blb:BBMN68_1706)

MetaCyc: 60% identical to L-1,2-propanediol oxidoreductase (Escherichia coli K-12 substr. MG1655)
Lactaldehyde reductase. [EC: 1.1.1.77]; 1.1.1.77 [EC: 1.1.1.77]

Predicted SEED Role

"Lactaldehyde reductase (EC 1.1.1.77)" in subsystem L-fucose utilization or L-rhamnose utilization (EC 1.1.1.77)

MetaCyc Pathways

• ethylene glycol degradation (2/2 steps found)
• L-lactaldehyde degradation (anaerobic) (1/1 steps found)
• methylglyoxal degradation VI (1/4 steps found)
• superpathway of glycol metabolism and degradation (3/7 steps found)
• nucleoside and nucleotide degradation (halobacteria) (1/6 steps found)
• superpathway of fucose and rhamnose degradation (3/12 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.77

Protein Sequence (383 amino acids)

>BBR_RS18225 lactaldehyde reductase (Bifidobacterium breve UCC2003)
MVYRMIFNQTAYFGRGAIKEIPAVAKQHGFTKAFIVTDPVLLETGTAEKVTKVLDEAGLP
YEVFSNVKPNPPVECIKDGVAKFAESGADFLIGLGGGSPQDTCKGIGIITANPEFADVLS
LEGVADTKNPSVPIFGVPTTAGTASETTINYVVTDTANKRKFVAVDPHDIPIVAFVDPDL
TDSMPRGLKVATGLDALTHAIEGYITPGAWSLSDCLSMQTIRMIAKNLAKSADGDIPAGE
QMAYASYITGMAYSNVGLGLVHGMAHPLGGRLGVAHGVANGILLAPVMEYNKDFTGEKYR
DIADAFGVEDAYTGDLEKVREEAVQAVHKLTVDLKNPTTISEVGATETDLAPLAHDAFND
VCTPGNPRQATEEDILKIYTSLM