Protein Info for BBR_RS18165 in Bifidobacterium breve UCC2003

Annotation: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00526: FolB domain
  • amino acids 1 to 119 (119 residues), 101.9 bits, E=4.2e-33
• TIGR00525: dihydroneopterin aldolase
  • amino acids 2 to 117 (116 residues), 109.8 bits, E=1.7e-35
• PF02152: FolB
  • amino acids 4 to 116 (113 residues), 118.8 bits, E=1.8e-38
• TIGR01498: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
  • amino acids 161 to 291 (131 residues), 119 bits, E=2.2e-38
• PF01288: HPPK
  • amino acids 162 to 291 (130 residues), 116.6 bits, E=8.5e-38
  • amino acids 387 to 502 (116 residues), 31.7 bits, E=1.9e-11

Predicted SEED Role

"Dihydroneopterin aldolase (EC 4.1.2.25) / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3)" in subsystem Folate Biosynthesis (EC 2.7.6.3, EC 4.1.2.25)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (9/12 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) (2/3 steps found)
• superpathway of tetrahydrofolate biosynthesis (7/10 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (3/5 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (2/5 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis V (Pyrococcus) (1/4 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus) (2/7 steps found)
• tetrahydromethanopterin biosynthesis (2/14 steps found)
• superpathway of chorismate metabolism (32/59 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.3 or 4.1.2.25

Protein Sequence (536 amino acids)

>BBR_RS18165 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase (Bifidobacterium breve UCC2003)
MDTITLTGVHANGTHGVLAFEHERPQMFVVDVTLHLDLGQAGQSDDLEDTIDYGRMAKDI
VSVIEGEHVDLIERLAQLIADRILADAPAVEVIDVTVHKPHAPIVVAFADVSVSITRARS
DSGKAAARMDEASSTVTGVSSVLAPNAISGAAVPPPTIHNAVVALGGNVGEVETTLRAAV
REIDVLPGTQVTGISPLYRTAAWGMADGTPDFLNAMVELETTMGSHELLASLQGIEARHG
RVRENHWDSRPLDLDIIDYDGITSADPDLALPHPRAWQRAFVLAPWAALNPNARLAGAHG
GPVASLLAVAPDRNAVQLESEDWMLSGHADSDTSVPAGGSRQPHADWGWSAAENHPQSRS
ASQLPPARAAESDEAVETQPVSRKAIISLDSTSHDAERLFREAIVSIDSIPGNQVQGISP
LYHVSRFDGPDAMSAVVQIETKLPAADLIAVLGSIEAAHELTVDLDLVDMEGVTSDEPNC
SVPWPSARNHASVLAPWLDMDPDATLGGDPVSFLLAMAPDAGQVGLLSDNWVLPPQ