Protein Info for BBR_RS18075 in Bifidobacterium breve UCC2003

Annotation: Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 395 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF13458: Peripla_BP_6" amino acids 44 to 385 (342 residues), 229.3 bits, see alignment E=1.7e-71 PF13433: Peripla_BP_5" amino acids 45 to 239 (195 residues), 51.5 bits, see alignment E=1.3e-17 PF01094: ANF_receptor" amino acids 67 to 383 (317 residues), 120.5 bits, see alignment E=1.3e-38

Best Hits

KEGG orthology group: K01999, branched-chain amino acid transport system substrate-binding protein (inferred from 98% identity to blf:BLIF_1608)

Predicted SEED Role

"Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1)" in subsystem ABC transporter branched-chain amino acid (TC 3.A.1.4.1) (TC 3.A.1.4.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (395 amino acids)

>BBR_RS18075 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein (Bifidobacterium breve UCC2003)
MNVKFSTKFIAASAAAVMALSLAGCSGGSMDDSSSSSAKASGDTITIGTVTTNSGTAAAY
GEAEVKGFELAVSEINAKGGINGKKVKLESMDDKGDATEASNAYNKLVGDNNVLAVAGPT
ISATTAAVAPLADQSKLVTIAPAATSDSIETGNYLFRTCFKDSYQGEVAARFAAENLKVK
KVAVLYGTGDPYSSGVGEAFAKAAEKLGLEVVDKESSSSADDTEYSAQLQKIQASGAELL
YAPYYYSVAGPYIIPQARSVGFDGYVMGPDGYDGLKLTGDKAQYNKTYYTTHYSADDNTN
SKVQDFIKSYKSKNNAEPNTFAALGYDTIYMIKQAIEKAGKNATREDVRNAVAGMTFDGV
TGKFTMDKSGSPTKSVIVLEMKDGKPVYNTTVQPK