Protein Info for BBR_RS17960 in Bifidobacterium breve UCC2003

Annotation: Ppx/GppA family phosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02541: Ppx-GppA
  • amino acids 36 to 314 (279 residues), 232.5 bits, E=3.7e-73

Best Hits

Swiss-Prot: 50% identical to Y3348_STRCO: Uncharacterized protein SCO3348 (SCO3348) from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

KEGG orthology group: K01524, exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC: 3.6.1.11 3.6.1.40] (inferred from 96% identity to bll:BLJ_1555)

Predicted SEED Role

"Exopolyphosphatase (EC 3.6.1.11)" in subsystem Phosphate metabolism (EC 3.6.1.11)

MetaCyc Pathways

• polyphosphate metabolism (2/2 steps found)
• ppGpp metabolism (3/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.11, 3.6.1.40

Use Curated BLAST to search for 3.6.1.11 or 3.6.1.40

Protein Sequence (322 amino acids)

>BBR_RS17960 Ppx/GppA family phosphatase (Bifidobacterium breve UCC2003)
MVNLRSHTTRLGVLDIGSNTIHMLIVDAAPGARPDPEASTKSTVRLMKYLKDDGSIKKSG
IEAILAAVAQCMKLAEEYEITQLLVMATSALREAPNGNKVIHKIEEMIGQGVTVLSGNDE
ARLTFLAARRWYGWDAGRLLVLDIGGGSLEVAMGSDEEPTVALSVPAGAGRVTTEFLPSG
MATPEELEDVRKDVRKILAPMVKVFPQSKHPNHAVGTSKTFRSLARLCGAVMRASGREDT
WIMTREQLEDWIPRLAAIAPEQRVALPGITPERTMQIVGGGVVADEIMKALNIQEVEICP
WALREGAILRWLDQFGRTRLGF