Protein Info for BBR_RS17915 in Bifidobacterium breve UCC2003

Annotation: anaerobic ribonucleoside-triphosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 PF03477: ATP-cone" amino acids 26 to 116 (91 residues), 68.7 bits, see alignment E=8.1e-23 PF13597: NRDD" amino acids 142 to 779 (638 residues), 596.1 bits, see alignment E=1.2e-182 TIGR02487: anaerobic ribonucleoside-triphosphate reductase" amino acids 325 to 779 (455 residues), 423.9 bits, see alignment E=5.3e-131 PF01228: Gly_radical" amino acids 657 to 761 (105 residues), 90.4 bits, see alignment E=1.6e-29

Best Hits

KEGG orthology group: K00527, ribonucleoside-triphosphate reductase [EC: 1.17.4.2] (inferred from 98% identity to blm:BLLJ_1509)

Predicted SEED Role

"Ribonucleotide reductase of class III (anaerobic), large subunit (EC 1.17.4.2)" in subsystem Ribonucleotide reduction (EC 1.17.4.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (802 amino acids)

>BBR_RS17915 anaerobic ribonucleoside-triphosphate reductase (Bifidobacterium breve UCC2003)
MGAQVLEENVTNNGTKAAAKASTVLVEKRDGRVVDFDPINIISAIKSAFGDLNKEVGPEE
DAMIRGFADQVEGEIKERYAGPAKIEDIQNLVEHALIDAHLYDVARAYTNYRLDKDIQRA
KATDVNEAVSRFINHDPTLIHENANKDSNVYSTQRDLLAGAVSKAAAFNMLPPAVSNAHM
KGDIHFHDADYSPFTAQSNCSLPNFWDMLANGFTLGNAPMASPKSIAIAATQITQIMKDV
ASSQYGGQTANRADEHLARYAKKDYEKFLEEARETIPDGMPVEFARRQVESAKKNEPAKL
HFGSREPLPMDTPFHTDVDELEQEREILAKIRTRKAIYDAMQTMEYQINSNRVSNGQTPF
VTVGFGLGTDWFSREIQRAILLNRIRGLGKEHHTAIFPKLVFTVKHGVNADPGDPNYDLK
QLALESATKRMYPDVVFYENIVKITGSFKAPMGCRSFLQGWINPETGKDEEDGRMNLGVV
TVNVPRIAIESHGDKARFWKLFDERMEVAHQALQFRIMRCKEATPVNAPTLFRFGAFGRL
GANDNVDALFKNERATVSLGYIGLAETTAVFYGKNWIRDHGWDPEGKEFALSIVKRMNEL
CKQWSKSEGYHYSVYSTPAESLTDRFNRMDREKFGRIEGVTDHDFYTNSFHYPVWLQPTP
MEKLNYEKDFPYYASGGFINYCEYPCLQDNPKALEAVWDYAYNIGIGYLGTNTPIDHCFV
CGFQGDFEPTEEGFKCPECGNSNPDKCNVTKRTCGYLGSPVQRPMVHGRHEEIAHRVKHM
SGETGRVTLDDGTTREWFEEAK