Protein Info for BBR_RS17905 in Bifidobacterium breve UCC2003

Annotation: 2-hydroxyglutaryl-CoA dehydratase activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1600 1701 PF01869: BcrAD_BadFG" amino acids 21 to 279 (259 residues), 62.5 bits, see alignment E=4.9e-21 amino acids 351 to 605 (255 residues), 121.5 bits, see alignment E=4.8e-39 TIGR00241: putative CoA-substrate-specific enzyme activase" amino acids 351 to 603 (253 residues), 131.4 bits, see alignment E=2.1e-42 PF09989: DUF2229" amino acids 753 to 971 (219 residues), 267.7 bits, see alignment E=7.9e-84

Best Hits

Predicted SEED Role

"Activator of (R)-2-hydroxyglutaryl-CoA dehydratase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1701 amino acids)

>BBR_RS17905 2-hydroxyglutaryl-CoA dehydratase activator (Bifidobacterium breve UCC2003)
MVDIVTDASVKPASHPKPLRVGLDIGSTTVKAVVLDQSDSLKDTLFSDYRRHHANVRATV
AGLLADIHKKLVELGRGDEPIRLSITGSGGLALADNLHVPFIQEVIAETEAIDKEYPQAD
VIIELGGEDAKITYLKPTPEQRMNGSCAGGTGAFIDQMSTLLDTDAAGLNEMAKSYENLY
PIASRCGVFAKTDLQPLINDGAAKPDLAASIFTAVATQTIAGLASGRPIHGTVIFLGGPL
FFMSELRAAFQRALEGKVDEFIVPTDAHLYVAYGSALQADMDSDDQGHHFEAYTCDEILK
RLDELKNLPSNTPTMPPLFPTEADREDFNKRHHKEHIHIGTLEGAHGPHFLGIDAGSTTI
KATLVNDDREIVWSSYANNEGSPLTAAINIVKKIQSELPEGAWIARSCATGYGEGLITTG
LHLDEGVVETMAHYRGAEMVSPGVTAVIDIGGQDMKYLAITDGVIDSIAVNEACSSGCGS
FLQTFAMSMGLTIQEFTQKALASTHPVDLGSRCTVFMNSSVKQAQKEGASIEDIAAGLCY
SVVRNALYKVIKLRDSGELGDTVVVQGGTFLNDAVLRAFELLTERQVTRPNIAGLMGAFG
AALTARMHYQDEADHLDVVVKADGSEEQSEAEPALKSEPKAAAFKKTEPAKPEVHVVVVD
GVTHTASSILTGDALDNMSMTTERDVCKLCQNHCKLTITTFSDGSRFVTGNRCERGGDAK
KKRSDRPNLYDYKYKRCFAYRRLTDKKATRGEIGVPRALNMYENYPFWFTLLTSLGFKVM
ISGRSSHELFETGIESIASENICYPAKLVHGHIKWLINKGIKTIFYPCVSYEENLVPNTD
NHYNCPVVANYPLVVGANMPELREDDVRYMHPYFNLANHELMVDRIVEEFAWANVTREEA
ETAVKAAYAEDKVFKHDVQQEGLTALAYMKEHNCRGIVLAGRPYHIDPEINHGIPETICS
LGMVVLSEDSICELQPGEKLNLTEFLSEGEADPRSKNAAGFRHVGDRTVTKMPLRVTNQW
AYHSRLYAAAHFVASYPGLELVQLNSFGCGLDAITTDQVAEILADKADVYTLLKIDEVSN
LGAAKIRLRSLKAAVEEREANKAREAAAAKALEDQQAAAERAAEEAKVKAESDLEAAKAV
LAEAQAAVEAAQKKVDAEAKAVQDAVKTSQATTAKTVQGPKSTGFRKTGSAAPTPGRQIL
LDTTMAANPNLTKSMRDASKRAAERDLRAAVDSKNGASDGTTGVTTAKKSGHNNATMSRY
AHREKFVKDMKKNYTIVGPQMSPIHMSLVEAVIRSGGYKFDILKHASRGDVETGLKYVNN
DACYPAIMVVGQLIDAILEGKYDPDHVALAITQTGGMCRATNYFGLIRKALVDAGYPQIP
IIAISTQGLEDNPGFKATLPLLHRAIKALILGDLLMKCLYRVRPYEVEKGSANKLYELWD
TIVREAIEHHGYSKTAARAPSIKKGYLPYNVLAKEIVKSFDALPLRDIPRKVRVGVVGEI
LVKYQPDANNHVVDVIESQDCEAVVPGIMEFMTTRPYITDWNEKNLGMGGNKTLYALMRK
GLDLYNAPIKAALATSHGKFKQDEPMPELVKKAAEVTSIGVQAGEGWLLTAEILELIEQG
CPNVICAQPFACLPNHVTGRGMFGKIRRLHPEANIVSIDYDPGASEANQLNRIKLMIAAA
KKAHNAKFAETGEPQGFTSAD