Protein Info for BBR_RS17470 in Bifidobacterium breve UCC2003

Annotation: chaperonin GroEL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 TIGR02348: chaperonin GroL" amino acids 2 to 527 (526 residues), 788 bits, see alignment E=1.9e-241 PF00118: Cpn60_TCP1" amino acids 22 to 525 (504 residues), 259.9 bits, see alignment E=2.4e-81

Best Hits

Swiss-Prot: 99% identical to CH60_BIFLS: 60 kDa chaperonin (groL) from Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)

KEGG orthology group: K04077, chaperonin GroEL (inferred from 99% identity to bll:BLJ_1477)

MetaCyc: 55% identical to chaperonin GroEL (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Heat shock protein 60 family chaperone GroEL" in subsystem GroEL GroES or Staphylococcal pathogenicity islands SaPI

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (541 amino acids)

>BBR_RS17470 chaperonin GroEL (Bifidobacterium breve UCC2003)
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEID
LEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIE
KATEVIVKELVVAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNR
FGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMK
TGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVS
DELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDR
EKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQA
AAKAEKAEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINKVRSLPDGEGFN
AATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKAAAPAAGADMG
Y