Protein Info for BBR_RS17125 in Bifidobacterium breve UCC2003

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1185 TIGR00594: DNA polymerase III, alpha subunit" amino acids 8 to 1061 (1054 residues), 1228 bits, see alignment E=0 PF02811: PHP" amino acids 11 to 197 (187 residues), 156.3 bits, see alignment E=2.3e-49 PF07733: DNA_pol3_alpha" amino acids 320 to 586 (267 residues), 299.7 bits, see alignment E=5.5e-93 PF17657: DNA_pol3_finger" amino acids 589 to 758 (170 residues), 209.4 bits, see alignment E=5.7e-66 PF14579: HHH_6" amino acids 831 to 921 (91 residues), 90 bits, see alignment 2.3e-29 PF01336: tRNA_anti-codon" amino acids 1024 to 1100 (77 residues), 51.7 bits, see alignment 1.7e-17

Best Hits

Swiss-Prot: 53% identical to DPO3A_MYCLE: DNA polymerase III subunit alpha (dnaE) from Mycobacterium leprae (strain TN)

KEGG orthology group: K02337, DNA polymerase III subunit alpha [EC: 2.7.7.7] (inferred from 97% identity to blj:BLD_0145)

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1185 amino acids)

>BBR_RS17125 DNA polymerase III subunit alpha (Bifidobacterium breve UCC2003)
MADYGKNFVQLHNHTHYSLLDGASKIPDLAKRAAELEMPAVGITDHGNMHGAYEMYTNCV
ANGVKPIIGIEAYVTPETARQDKSRVHWGTEAQRRDDVSGGGLITHLTMWAENDEGLVNL
IKASSVANLEGRVMRYPRMDKEVLSTYSKGVIASSGCPSGIIQTRLRLGQFDEALRAAGE
FQDIFGKDNFFIELMDHGLTIENQVTDDLLTIAKKLDAPLLATNDSHYVHAEDAGAQDAM
LCINSGSRLDDPDRFKFDGTGYYIKTAEEMRELFKDHPDACDNTLLIAERCNVMFDDHED
GAFMPQFPCPEGWDETSLFLKKVEEGLEKRYNGNPPLNVLKQADYECGVICQMQFCGYFL
VVADYIQWAKDHGIMVGPGRGSAAGAMVAYSMGITELDPLKHGLIFERFLNPERVSLPDI
DVDFDPEGRARVIEYCGEKYGTDKVAQCVIYGTIKTKQALKDSARIMGYEFSVGEKVTKA
LPPAATGGKDISLHDIFDPSAKRYAEAREFREMYDSDPDAKRITEEAKGIEGLIRQTGVH
ACATIMGSAPITDTSPLLERTDGTITTTFEYHTCETLGLVKMDFLGLSNLTVIHDTLKNI
EANGKPAIDYTKIPLDDAETYKLMARGDTLGVFQLDSDGMRSLLKTLKPDNFNDISALIA
LYRPGPMSMDSHTNYAKRKNGLQKITPIHPELEEPLKQVLDETYGLIIYQEQVQSAARIL
AGYSLGKADVLRRAMGKKKPEVLAKEKVPFFAGMKEHGYSEEAANAVWDILVPFSGYAFN
KAHSAAYGLISYWTAYLKTHYPVEFMAALLQGAATNKDKTALYLGEARRMGIQVLSPDVN
ESVYAYSAVGDVVRFGLGAIRNVGDKAVADIIAEREGPRGKFVNFMDFIRRVPLTALNRR
LVESLIKAGAFDSIDPNRRALFTVHEAAIDSVVSLKRKQAEGQFDLFSDADDGGAEAMGD
ASVTVPDIEEWDKKTKLNFEREMLGLYVSDHPLSGMQSILASLREMSIAHLIDRAKTMGE
GQQVTLAGLITGVDRRVSKKGNPWAIVTIEDMESSIQCMFFGKVYEAAAAELAVDAIVQI
RGQVELRDETVSMRATELQVPTLESEDERPLTITLPHAALDRQHMMQLGQVLTNHPGYCE
VHLAVMDEKGNAQVLTFGDRFRVKRDTSLFAEIKILFGPSCLPAA