Protein Info for BBR_RS17065 in Bifidobacterium breve UCC2003

Annotation: aldo/keto reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00248: Aldo_ket_red
  • amino acids 25 to 261 (237 residues), 161.1 bits, E=1.7e-51

Best Hits

Swiss-Prot: 51% identical to YTBE_BACSU: Uncharacterized oxidoreductase YtbE (ytbE) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 90% identity to bln:Blon_0820)

MetaCyc: 46% identical to glyoxal/methylglyoxal reductase (Bacillus subtilis subtilis 168)
Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]; 1.1.1.91 [EC: 1.1.1.91]; Methylglyoxal reductase (NADPH-dependent). [EC: 1.1.1.91, 1.1.1.283]

Predicted SEED Role

"Aldo/keto reductases, related to diketogulonate reductase"

MetaCyc Pathways

• methylglyoxal degradation V (2/3 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• superpathway of methylglyoxal degradation (2/8 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.283 or 1.1.1.91

Protein Sequence (275 amino acids)

>BBR_RS17065 aldo/keto reductase (Bifidobacterium breve UCC2003)
MAIQSTITLNDGTVIPQVGLGVFQTPDGDTTVNAVQTALENGYRHIDTAMIYRNEASVGE
GIRRAGLPRGDFFVTTKLWNDDIRAHRGKDAFQESLDRLGLDYVDLYLIHWPADGWQQAW
DDMQEIYASGRAKAIGVSNFQKHHIDELLANSDVLPAVDQIESSPQFTNHELIGQLRSKG
IVAEAWSPLGGTGGDLLGSPVLAEIGAKYGKSAAQVVIRWHIQRGVVVLPKSTHAERIKQ
NFDVFDFNLTSEDMTAITALNTGKRNGADPDNFDF