Protein Info for BBR_RS17055 in Bifidobacterium breve UCC2003

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 PF00815: Histidinol_dh" amino acids 27 to 444 (418 residues), 496.3 bits, see alignment E=3.7e-153 TIGR00069: histidinol dehydrogenase" amino acids 39 to 444 (406 residues), 467.7 bits, see alignment E=1.9e-144

Best Hits

Swiss-Prot: 97% identical to HISX_BIFLO: Histidinol dehydrogenase (hisD) from Bifidobacterium longum (strain NCC 2705)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 96% identity to blm:BLLJ_1303)

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>BBR_RS17055 histidinol dehydrogenase (Bifidobacterium breve UCC2003)
MSENIMRIIDLRGRKLSRAELLAAMPRAAMGTSEATDLVRPILDDVKERGAAALRDFEEK
FDHVRPKHLRVPVEAIQDALATLDPEVRAAIEESVRRARAVAANQVPKDFYTDLAEGARV
AERWIPIQRVGLYVPGGKAVYPSSVIMNAVPAQAAGVESLAIATPPARDNEEGLPNKTIL
ATCAILGVDEVYAVGGAQAIAMFAYGAKGSEPQDGDVLCDPVDKITGPGNIFVATAKSLV
SAFVGIDAVAGPTEIGIIADKTANPSLLAADLIGQAEHDELAGSVLFTDSTDIAEKVQEN
LNYRVPKTEHAERVHTSLSGTQSAIVLTDNLDQSIDAANAYAAEHLEIQTEDADAVVKRI
KNAGAIFRGPYSPVPLGDYMSGSNHVLPTGGTARFAAGLGVHTFMKPVEVIEYDQEGLKA
LAARINAFAVSEDLPAHGECVLSRFVKDPYDKATLREQEREAGLR