Protein Info for BBR_RS17010 in Bifidobacterium breve UCC2003

Annotation: DUF3418 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1378 transmembrane" amino acids 512 to 528 (17 residues), see Phobius details PF13245: AAA_19" amino acids 19 to 136 (118 residues), 25.9 bits, see alignment E=3.9e-09 PF00270: DEAD" amino acids 19 to 166 (148 residues), 40.6 bits, see alignment E=9.5e-14 PF00271: Helicase_C" amino acids 268 to 399 (132 residues), 33 bits, see alignment E=2.5e-11 PF21010: HA2_C" amino acids 497 to 558 (62 residues), 22.2 bits, see alignment (E = 7e-08) PF07717: OB_NTP_bind" amino acids 648 to 750 (103 residues), 47.3 bits, see alignment 7.9e-16 PF11898: DUF3418" amino acids 765 to 1377 (613 residues), 408 bits, see alignment E=3.2e-125

Best Hits

KEGG orthology group: K03578, ATP-dependent helicase HrpA [EC: 3.6.4.13] (inferred from 95% identity to blb:BBMN68_190)

Predicted SEED Role

"FIG003033: Helicase domain protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1378 amino acids)

>BBR_RS17010 DUF3418 domain-containing protein (Bifidobacterium breve UCC2003)
MKYEYPAELPVSAARDEIADAVRRSQVVIVSGQTGSGKTTQLPKILLELGQGTHGKQIVH
TQPRRIAARTVAERIASEMGVRLGDEVGYQVRFTDESSPNTRLRVVTDGILLAQIQRDPK
LSQYDTIIIDEAHERSLNIDFLLGYLTALLPQRRDLKLIITSATIDSVKFQEHFAHALHE
KVPVIEVSGRTFPVQVVYEPLGTAPALMREVPGFATGARPGDADYDELASAIAESDADHS
RRRGNADYADDGITDMPTAVARACAELVIHSSHERGPRDILVFASGERDIHEFEAALRHH
YGPRADDMHRPDAIEIMPLFARLSAADQHKVFESHTHQRIVIATNVAETSLTVPGIRYVV
DPGTARISRYSKTAKVQRLPIEPISQASADQRSGRCGRVADGIAIRLYSREDYETRPRFT
EPEILRTSLGAVVLHMLSVGVARTAEDVTNFGFIDPPDMKAVSDGFNELTELKAIGRKRG
EVTLTHTGRQLARIPIDVRLGRMVIEAAKAGSPNLLASVLVVVAFLSLQDPRERPDDKRE
EADRIHNRYADETSDFLTALNIWDRVFQADGDPSNNALRRICRTEYFSWLRMRQWKDLVS
QLRQMCKELKFKVGDPLPSSRPGLEIRQLPLNQQAAHSLCCSWDTDGIHKSMLAGLLSMM
GMQVIREPKASDFAGLSGAARARAMKRAQKMSKNDYQGARGTRFALFPASAVAKKTPSWV
MSTELVETSRLWARYSAAIDPAWAEPLAGQLTRTTYAEPHWSGSRGSAVATARVLLYGLP
IVQDRAVQWGRINPLEARDFLIRQGLVEGDIQQRFSYDEFVGRNRDILEDAADDASRTRQ
LADTVSDEDLFDFYNAVIPNDVTCVADLAKWWKIDHDKQPDLLDFDPAKVERLASSDSVS
LDDYPDHWHTTGSDGQPIDLRLSYVYDPTDLADGVTVHVPLKALSRITPDQFTWNVPGLL
DELILAMIKALPKQLRVQFVPAPDAARSIRDWINEHYPDLPGSGSQQKPNLPPVDEEGTT
VGWPDLAHVFTKAAIATVGAQIHPEVLGPELVERLSPYLRVTFSVEQQLPAGKHPRGRRH
ARGPVKVLGTAKDLKALQREFAAQAEASARQMVKKQAEQAGEQGKLVQQANLLHKAGATT
ESRATMLWRGALDALRLPGERISSRWLGTEALMLAAAPYKSTKALVEDLQLATVKRLLPN
VDKLTDDEALANAVLDIREVYEDTVYQVAHDVIGIMKSYADVDKATSGKADLPMLSVLQS
IRDHIATLVYPGFIGRTPPDALKSLSRYLKADVSRLNKAKTDKNRDVKWAWQADEAKQLV
DKALARAKAEPAGPKHEALTQQAEQARWMLEEFYVSLWAQELGTKGPASLNRIKKALF