Protein Info for BBR_RS16760 in Bifidobacterium breve UCC2003

Annotation: glycerate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00045: glycerate kinase
  • amino acids 2 to 381 (380 residues), 470.2 bits, E=2.4e-145
• PF02595: Gly_kinase
  • amino acids 3 to 379 (377 residues), 477 bits, E=2e-147

Best Hits

Swiss-Prot: 51% identical to GLXK_BACHD: Glycerate kinase (glxK) from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

KEGG orthology group: K00865, glycerate kinase [EC: 2.7.1.31] (inferred from 65% identity to bde:BDP_1377)

MetaCyc: 47% identical to glycerate 2-kinase 2 (Escherichia coli K-12 substr. MG1655)
GKI-RXN [EC: 2.7.1.165]

Predicted SEED Role

"Glycerate kinase (EC 2.7.1.31)" in subsystem Allantoin Utilization or D-galactarate, D-glucarate and D-glycerate catabolism or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Glycine and Serine Utilization or Photorespiration (oxidative C2 cycle) or Serine-glyoxylate cycle (EC 2.7.1.31)

MetaCyc Pathways

• 2-O-α-mannosyl-D-glycerate degradation (1/2 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
• D-glucarate degradation I (1/4 steps found)
• D-galactarate degradation I (1/4 steps found)
• glycolate and glyoxylate degradation I (1/4 steps found)
• superpathway of glycol metabolism and degradation (3/7 steps found)
• superpathway of D-glucarate and D-galactarate degradation (1/5 steps found)
• 2-deoxy-D-ribose degradation II (2/8 steps found)
• photorespiration II (3/10 steps found)
• formaldehyde assimilation I (serine pathway) (5/13 steps found)
• photorespiration I (2/9 steps found)
• photorespiration III (2/9 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (5/31 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glycine, serine and threonine metabolism
• Glyoxylate and dicarboxylate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.165 or 2.7.1.31

Protein Sequence (384 amino acids)

>BBR_RS16760 glycerate kinase (Bifidobacterium breve UCC2003)
MKFVIAPDSFKGCMTAKQACAAIRDGLLRVFPDAEYVMVPMADGGEGTVRSLVDATHGRI
CSAQVLDPLQRETVAEYGILGNANDSGLTAIIEMSAASGIQFVDEHTRNPLVATTYGTGQ
LMKQALDDGVRTIILGVGGSATNDGGAGMAEALGVRFLDEHGNPIPRGGGFLDRLATVDA
SGLDPRIANTCILIASDVTNPLVGPTGASAVFGLQKGATPQMVTQLDNNLAHYAAVIKDQ
LGIDVAHTPGAGGAGGLGAGLLAFTQSTMRAGVDIVSSTVRLVERAEGADYCFTGEGGID
FQTKFGKTPMGVAKAVRERNPHIGVVAFAGHVGEGIDQLYDVGVDAVFGIVPGAMPLNEA
IADGPRNLIRAAENVGRLIRLGRR