Protein Info for BBR_RS16730 in Bifidobacterium breve UCC2003

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 70 to 424 (355 residues), 316.6 bits, E=8.6e-99
• PF02445: NadA
  • amino acids 76 to 422 (347 residues), 345.9 bits, E=8.9e-108

Best Hits

Swiss-Prot: 69% identical to NADA_CORGL: Quinolinate synthase A (nadA) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 97% identity to bll:BLJ_1227)

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• NAD de novo biosynthesis I (6/6 steps found)
• NAD de novo biosynthesis III (5/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (5/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (426 amino acids)

>BBR_RS16730 quinolinate synthase NadA (Bifidobacterium breve UCC2003)
MTASFIAPSVDEIIAKLGAQSTCDAGLTQDPWHFDTTTPSYGPGASMLDRLPANAPRQQV
LPDEYRKASDEELQQRITDAKQRLGSKLLILGHFYQRDEIIKHADFVGDSFQLAKNATER
PDADHIVFCGVHFMAETADILSTPEQSVTLPNLSAGCSMADMANIDQVQECWDQLGEICG
TEPDSDGRQQIIPVTYMNSSAALKAFCGRNGGIVCTSSNAHAVLEWAFARGKRVLFFPDQ
HLGRNTARAMGIPLSEMPLWDPFKAQGGASDPADYARAKMILWKGFCSVHQRFTVEQIER
ARKAYPGVKVIVHPECSMQVVDAADGTGSTAYIVKEIANAPAGSAIAVGTEINLVNRLAA
QYPDKTVFCLDPVVCPCSTMYRIHPAYLAWALENLEQGNVVNRIIVDDNTAREAKVALER
MLRVHP