Protein Info for BBR_RS16430 in Bifidobacterium breve UCC2003

Annotation: nucleotide pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01663: Phosphodiest
  • amino acids 72 to 393 (322 residues), 102 bits, E=5.4e-33

Best Hits

KEGG orthology group: None (inferred from 86% identity to blf:BLIF_1207)

Predicted SEED Role

"Alkaline phosphodiesterase I (EC 3.1.4.1) / Nucleotide pyrophosphatase (EC 3.6.1.9)" in subsystem Purine conversions (EC 3.1.4.1, EC 3.6.1.9)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (13/18 steps found)
• pyrimidine deoxyribonucleotides dephosphorylation (2/3 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (6/9 steps found)
• dZTP biosynthesis (3/5 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (4/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (9/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (5/9 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism
• Pantothenate and CoA biosynthesis
• Purine metabolism
• Riboflavin metabolism
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.4.1 or 3.6.1.9

Protein Sequence (420 amino acids)

>BBR_RS16430 nucleotide pyrophosphatase (Bifidobacterium breve UCC2003)
MSVETPDMDELLRLVPTVTYGDTAAGRGGALHLSAVLPALSAAIGHPISTKVHTDPQACK
KALGLPDATSAIVVLVDGLGYWNLAMRLGHAPYLRSLMNESANQRPIATCAPSTTVAAMA
TFGTGTCPGLTGMAGYTQLEPNNHKLIQLIQFKDALAPKPVNPRITTPPMVDPHDLQREQ
TVFEKLRRQEVRVTSSGLPKFAGSPLTEAALRGTDYQANVTPRDRVLAAARAARRPGLTY
LYIRDADKVGHNYGWDSEHWVAAFEHIDAQLALLKRSASAGTLIVIIADHGMVQTDMDQR
LDIATEPSLIHGVELVGGEPRSLMLYAEPGESPDAIADRWRDRLGDAALVRTKEQACADG
LFGPVSERIRPILGDVMVQAAGAATFVDSRTQGDKATHLPSVHGSQTMMEMDIPCLIDVA