Protein Info for BBR_RS16405 in Bifidobacterium breve UCC2003

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 179 PF00160: Pro_isomerase" amino acids 4 to 177 (174 residues), 154.3 bits, see alignment E=1.7e-49

Best Hits

Swiss-Prot: 57% identical to PPIB_STRAQ: Peptidyl-prolyl cis-trans isomerase B (cypB) from Streptomyces anulatus

KEGG orthology group: K03767, peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC: 5.2.1.8] (inferred from 96% identity to blm:BLLJ_1157)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (179 amino acids)

>BBR_RS16405 peptidylprolyl isomerase (Bifidobacterium breve UCC2003)
MTTVIMRTSEGDITINLFDDKAPNTVANFLGLATGEKEWADPYTGQPSHGKFYNGLTFHR
IIKQFMIQGGCPLGTGTGGPGYEFDDEIDPSLKFDKPYLLAMANAGLRRGMDGKVHGTNG
SQFFITTVPTPWLDGHHTIFGEVADDASKKVVDKLEAVETDPMDRPLEPAVILSVDVAE