Protein Info for BBR_RS16085 in Bifidobacterium breve UCC2003

Annotation: anthranilate synthase component I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00564: anthranilate synthase component I
  • amino acids 40 to 509 (470 residues), 527.3 bits, E=1.9e-162
• PF04715: Anth_synt_I_N
  • amino acids 41 to 183 (143 residues), 81.7 bits, E=6.8e-27
• PF00425: Chorismate_bind
  • amino acids 243 to 501 (259 residues), 314.4 bits, E=6.3e-98

Best Hits

KEGG orthology group: K01657, anthranilate synthase component I [EC: 4.1.3.27] (inferred from 97% identity to blj:BLD_0413)

Predicted SEED Role

"Anthranilate synthase, aminase component (EC 4.1.3.27)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Tryptophan synthesis (EC 4.1.3.27)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (4/4 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-glutamate and L-glutamine biosynthesis (5/7 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• 4-hydroxy-2(1H)-quinolone biosynthesis (2/5 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)
• acridone alkaloid biosynthesis (1/4 steps found)
• superpathway of quinolone and alkylquinolone biosynthesis (2/10 steps found)
• superpathway of chorismate metabolism (32/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.27

Use Curated BLAST to search for 4.1.3.27

Protein Sequence (518 amino acids)

>BBR_RS16085 anthranilate synthase component I (Bifidobacterium breve UCC2003)
MSECSVEHLKWGATWPSREQFHELADAGYRVVPIVRRLLADSLTPVGFYERLAGGRSGTF
ILESAEYGGTWSRYSFIGVNSMAQLRSNNGQADWLGKVPVGVPTEGDVIEVAHAALKALK
APQVAGLPNLTSGLVGTVGWDAIRHWEPTLRAEAPDETGQPETVLALATDIAVVDHISGS
VWLIANAVNVDNKSTRADAAYNEAVARLNQMQRDAATPAPDEFRVNILDETVAQPELRFR
TEKSHYEQAVERAKQHIVDGDVFQVVISQRLDIDSPADPFDVYRVLRTLNPSPYMYFMAL
TDAQGRDFNVIGSSPETLIKVDNGHAMTFPIAGSRPRGATPEEDEKFAKELLADPKERSE
HIMLVDLSRNDLSKVCVPQSVEVVQLMDIKRFSHIMHICSTVTGKVDPSLTAFDVFKSAF
PAGTLSGAPKPRAVEIIDELEPADRGIYGGTVGYFDFSGNMDMAIAIRTAFLCDHEASVQ
AGAGIVLDSVPATEWQETRNKAESSVESIQIAAQLREL