Protein Info for BBR_RS15235 in Bifidobacterium breve UCC2003

Annotation: coproporphyrinogen III oxidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 TIGR00539: putative oxygen-independent coproporphyrinogen III oxidase" amino acids 4 to 280 (277 residues), 245.9 bits, see alignment E=3.3e-77 PF04055: Radical_SAM" amino acids 5 to 180 (176 residues), 82 bits, see alignment E=5.7e-27 PF06969: HemN_C" amino acids 353 to 423 (71 residues), 52.4 bits, see alignment E=4.6e-18

Best Hits

Predicted SEED Role

"Hypothetical radical SAM family enzyme in heat shock gene cluster, similarity with CPO of BS HemN-type"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>BBR_RS15235 coproporphyrinogen III oxidase (Bifidobacterium breve UCC2003)
MFEVYIHVPFCLRRCGYCDFNTYTATDLGAGASRGNYANMVIREMKSTKQWQLDHGIAEP
PVSTVFFGGGTPTILAARDLVAMLDAIRKTWGIASNAEITTEANPDTVNEYYINELAAGG
FTRVSFGMQSAVPHVLKTLDRTHTPANVAAGVNAANKAGLRSSVDLIYGAPGESLDDWRT
SVTTAIDLGVNHISAYALTVEPTTKMGRQIAAGTLPKPNDDDEAAKYEIADDLFAAAGLE
WYEVSNWARPGYESQHNLGYWRNVDWAGVGPGAHSHYNNVTEIDRPQSALLTAPASGGTT
EAIAPAGGGCPAEAGLGVVPVSHGLRSWDIAHPRLWGTAINEHRIPWADSEAITAEENLE
ELIMLGLRLREGLDLGRINQAIAANENTSWQTIAVDSLRPMIDEGLITISGNRVIPTRRG
RLLNDSVIERFFGLAGI