Protein Info for BBR_RS15185 in Bifidobacterium breve UCC2003

Annotation: NAD(P) transhydrogenase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 387 PF05222: AlaDh_PNT_N" amino acids 12 to 146 (135 residues), 111.1 bits, see alignment E=4.8e-36 PF01262: AlaDh_PNT_C" amino acids 151 to 357 (207 residues), 161.3 bits, see alignment E=2.4e-51

Best Hits

Swiss-Prot: 40% identical to PNTAA_RICPR: NAD(P) transhydrogenase subunit alpha part 1 (pntAA) from Rickettsia prowazekii (strain Madrid E)

KEGG orthology group: K00324, NAD(P) transhydrogenase subunit alpha [EC: 1.6.1.2] (inferred from 95% identity to bln:Blon_1579)

Predicted SEED Role

"NAD(P) transhydrogenase alpha subunit (EC 1.6.1.2)" in subsystem Phosphate metabolism (EC 1.6.1.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.1.2

Use Curated BLAST to search for 1.6.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (387 amino acids)

>BBR_RS15185 NAD(P) transhydrogenase subunit alpha (Bifidobacterium breve UCC2003)
MAQNPEATVVFGVLNETSETESRVALTPDIVTRLKRSGVSSIIETGAGIAAEYTDEDYEK
AGAKVTSRDEVLAQADALGFVDRPSTDIVSKLKAGQWVIGMLGSFTDADYVAALEQAGLV
GIAIEKLPRKLSSAQSMDEMTSQNSVMGYKAAITAADAYGAFLPMMTTAAGTIRPAKALV
LGAGIAGLQAIGTLKRLGAVVTAYDVRPASQGEVESLGAKFLDLGLDFSKGQDEGGYARA
LTPEEQAQQQAAVDEKAAGFDIIITTAKVPGRKPPVLLTAAGVNGLKRGAVIVDCAASDL
GGNVEGSAVGEQVTEGGVKLIGAPYLASGVATTASNLLSRNVADILVHFVRDGKLGQDLT
EELDDALVVAGRAGAPAAAAESEQSEK