Protein Info for BBR_RS14700 in Bifidobacterium breve UCC2003

Annotation: type II toxin-antitoxin system PemK/MazF family toxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 107 PF02452: PemK_toxin" amino acids 2 to 104 (103 residues), 76.5 bits, see alignment E=9e-26

Best Hits

Swiss-Prot: 41% identical to MAZF_MYCS2: Probable endoribonuclease MazF (mazF) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

KEGG orthology group: K07171, (no description) (inferred from 98% identity to bll:BLJ_0811)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (107 amino acids)

>BBR_RS14700 type II toxin-antitoxin system PemK/MazF family toxin (Bifidobacterium breve UCC2003)
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPEN
GLNKVSYVMTDKIVTVDRKLLGYQVGVVDDAAMANIGRQLMRVLGLL