Protein Info for BBR_RS14590 in Bifidobacterium breve UCC2003

Annotation: pyridoxine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08543: Phos_pyr_kin
  • amino acids 37 to 265 (229 residues), 80.6 bits, E=6.2e-27

Best Hits

KEGG orthology group: K00868, pyridoxine kinase [EC: 2.7.1.35] (inferred from 95% identity to bln:Blon_1697)

Predicted SEED Role

"Pyridoxal kinase (EC 2.7.1.35)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 2.7.1.35)

MetaCyc Pathways

• pyridoxal 5'-phosphate salvage I (3/6 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (6/12 steps found)
• 4-amino-2-methyl-5-diphosphomethylpyrimidine biosynthesis II (3/8 steps found)
• pyridoxal 5'-phosphate salvage II (plants) (3/9 steps found)

KEGG Metabolic Maps

• Vitamin B6 metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.35

Protein Sequence (290 amino acids)

>BBR_RS14590 pyridoxine kinase (Bifidobacterium breve UCC2003)
MSDVTLYDRDPKYIPRVAAVHDMCGYGKCSLTAAIPILSAAGCDVCPVPTALFSAHTKYA
VFTFHDTTDILSGYLNAWQKEDVELDGVYSGFLGSPDQVAIIQRLYREYPNALRLVDPVM
GDAGEMYPTYTPELCEAMGALADGADVLMPNLTEASILTKRDYPGQDIDEATVDELLGAL
LELGAKNVVLKGIDHGDGKIINYVASASTGVTGKIELAHDKLPYMIHGTGDAFASALCGA
VMAGRGLAESAEIAGEFVRHAMESTRNQPHFEDRGVSFELNLGELTNLVK