Protein Info for BBR_RS14495 in Bifidobacterium breve UCC2003

Annotation: trigger factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 PF05697: Trigger_N" amino acids 1 to 149 (149 residues), 144.4 bits, see alignment E=4.6e-46 TIGR00115: trigger factor" amino acids 11 to 396 (386 residues), 352 bits, see alignment E=2.1e-109 PF00254: FKBP_C" amino acids 161 to 217 (57 residues), 29 bits, see alignment 1.7e-10 PF05698: Trigger_C" amino acids 260 to 396 (137 residues), 66.1 bits, see alignment E=5.9e-22

Best Hits

Swiss-Prot: 97% identical to TIG_BIFLO: Trigger factor (tig) from Bifidobacterium longum (strain NCC 2705)

KEGG orthology group: K03545, trigger factor (inferred from 96% identity to blb:BBMN68_696)

Predicted SEED Role

"Cell division trigger factor (EC 5.2.1.8)" in subsystem Bacterial Cell Division (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (457 amino acids)

>BBR_RS14495 trigger factor (Bifidobacterium breve UCC2003)
MKISVRNLEPTKVKLTVTVEPEELNPYLDAARKEIAKQVNVPGFRKGHVPGKIIDQRIGF
AAVAGEAVNDAVPELYSKALDEKKIRPMAQPEFDVQDVPQAANDDTKLKFTATVERRPDI
ELPEIDGLEIAIAKPEVKDEDVDKRLEALRQRFGTLVGVDRPATKGDFANIDLTAEIDGE
TVDSQEGVSYELGSNTMLDGLDEALDGLSAGEETTFEGTLEAGDHEGQKATVKVKVNSVK
AEELPELDDEFASEASEFDTLDELKADIRKAAAQDAEGRQATEARDAFIAKLQEGLEIPV
PKGVKANMVAEQLKGMTPDPEKATKEQKAQAEETVEKELRDQMVLDALAEKLDVQVSQSD
VFNFLASIAQQYGMDPNNFIQAIIKNGQLGSAVQEVGRSKGLLAGMRAVKFTADGEAVDL
SNFLGEAAEEEESESVEAASAAAAVADELSSKDKDAE