Protein Info for BBR_RS14315 in Bifidobacterium breve UCC2003

Annotation: DNA polymerase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 PF02739: 5_3_exonuc_N" amino acids 8 to 175 (168 residues), 186.2 bits, see alignment E=5.6e-59 TIGR00593: DNA polymerase I" amino acids 9 to 947 (939 residues), 857.1 bits, see alignment E=1e-261 PF01367: 5_3_exonuc" amino acids 177 to 270 (94 residues), 97.4 bits, see alignment E=8.9e-32 PF00476: DNA_pol_A" amino acids 566 to 947 (382 residues), 464.7 bits, see alignment E=3.6e-143

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 83% identity to blf:BLIF_0651)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (951 amino acids)

>BBR_RS14315 DNA polymerase I (Bifidobacterium breve UCC2003)
MTEPTNETLLVVDGHSLAFRAFYALPVENFSTAAGQATNAVWGFATMLSQVIEAEKPDHL
GVAFDMKGGTFRNDMLPQYKGTREAAPEELLTQLPLIQRMLKALGVTYIEKQGYEGDDII
ATLATMGDDAGYHTLVLSGDRDAFQLVDDNVTVLYPGHHFKDLKHMTPQSIVDKYKVTPA
QYPDLAALRGETADNIPGVPGVGDGYAAKWINQYGSLDAICEHADEVTGKKGEALRANID
QVKLNRKVNALVRDVDLGVDIEDLTFGSVDVAQVDALFKELEFGPRTKTRVMKIFNGGVS
PAGTAQGAAAAQSDGPAEDDLGSGLDTPKITVIESAAQFEQWVEAHRHEINVPDDIVDFP
VSDYSNEAERHIMCGDAVGHAWTVTAWGDARPGRAHVQACAVATASSAAIIEAPMASSVQ
TALDRFLKAEHFRTIVHGYKELLHLLSAAGLGMALPMFDTKLGGYLAQPDFHADNLNQAA
EHFLDIHVVDAEQPAQGVLDFDDEHTEEDLNERRVHDLAVIRELAVTLGPVIDERRQYWL
MRAIELPVSRVLHGMEHSGAKIDRSRLTDMRDRFAADARQAQEMAWQYAGGEINLQSPKQ
LQKVLFVDMGLKPTKRTKNGSYTTNAAALQNLYIHSVDNEQANGFLGALLRHRETNKLKQ
IVQTLIDATNKADERIHTTFEQTVAATGRLSSVDPNLQNIPNRNAVGREIRSVFVPGEGY
EALMSCDYSQVELRIMADLSGDEALIEAFRSGADFHKYVASMVYGVPVDQITGDQRSHVK
AMSYGLAYGLSTYGLAQQLNIAQREAEALKNRYFDTFGKVHDYLESLVSTAREKGYTETI
FGRRRYFPALRSTNRMARDAAERAALNAPIQGSAADIMKIAMIRAGQALDEAGVKSRIIL
QIHDELVVEIAPGESEQVTELIRNAMEHAVDLAVPLDVSCGIGSDWQLAAH