Protein Info for BBR_RS14075 in Bifidobacterium breve UCC2003

Annotation: glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 15 to 298 (284 residues), 60 bits, E=8.4e-21
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 22 to 420 (399 residues), 461 bits, E=1.6e-142

Best Hits

Swiss-Prot: 94% identical to PROA_BIFLS: Gamma-glutamyl phosphate reductase (proA) from Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 94% identity to bll:BLJ_0672)

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (2/3 steps found)
• L-citrulline biosynthesis (5/8 steps found)
• superpathway of L-citrulline metabolism (7/12 steps found)
• L-N^δ-acetylornithine biosynthesis (3/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (431 amino acids)

>BBR_RS14075 glutamate-5-semialdehyde dehydrogenase (Bifidobacterium breve UCC2003)
MSDELSPEVFDAVCRQADQAVSAQQRLAQANTEAKNELLLAIADALDEHAADIEAANALD
MLESKENGMDAGKLDRLLFDTPRVAAAAQDVRHVATLPDPVGEIVRGYNLPNGLRLTQTR
VPMGVIGMIYEARPNVTVDVASLCLKSGNAALLRGGHAAERTNAATLSVIAPVLEAHGFD
PALVQSVDQYGRAGATAMMEARGHIDVLVPRGGAGLIQAVVRNSKVPVIETGAGNVHIYI
DRSADLVKAIPIVLNAKTQRVGVCNAAEKLLVHEDVAAEFLPQIAAALTQANVVLQADET
SYDILEGAAIEGLELNHATEEDWDTEYLALKMGIKVVPSLESAIDHINIHSTGHTESIIA
EDYAAIEEFTKRIDSAVVMVNASTRFTDGGVFGFGAELGISTQKMHARGPMGLREMTTTK
WIGYGTGQVRA