Protein Info for BBR_RS14010 in Bifidobacterium breve UCC2003

Annotation: TlyA family rRNA (cytidine-2'-O)-methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 257 TIGR00478: TlyA family rRNA methyltransferase/putative hemolysin" amino acids 14 to 249 (236 residues), 189.1 bits, see alignment E=3.6e-60 PF01479: S4" amino acids 14 to 57 (44 residues), 60.2 bits, see alignment 1.3e-20 PF01728: FtsJ" amino acids 69 to 254 (186 residues), 128.5 bits, see alignment E=2.9e-41

Best Hits

KEGG orthology group: K06442, putative hemolysin (inferred from 88% identity to bll:BLJ_0654)

Predicted SEED Role

"RNA binding methyltransferase FtsJ like"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (257 amino acids)

>BBR_RS14010 TlyA family rRNA (cytidine-2'-O)-methyltransferase (Bifidobacterium breve UCC2003)
MSEHPIDPAMPLDRLDMMLVASGLVESRSKAQRLIKAGHVRVDGETITKPSFMVKAGHCE
LAVDKGDDYVSRGAYKLLGAFKAFADDGLTGPQSLECLDIGASTGGFTDVLLRGGAARVV
ALDVGHGQLDPRIAGDSRVIEMSGVNIREVTADDLPYRPAMIVSDVSFISLTYVIPVIAR
IAAPGAQVVLLVKPQFEVGRQGLGKHGIVGDPALREQTLADVVACARQHGLHVVNMADSP
IEGMHGNAEYLLYAVFK