Protein Info for BBR_RS13565 in Bifidobacterium breve UCC2003
Annotation: DNA-(apurinic or apyrimidinic site) lyase endonuclease III base excision repair
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K07457, endonuclease III related protein (inferred from 96% identity to blo:BL1081)Predicted SEED Role
"Endonuclease III (EC 4.2.99.18)" in subsystem Control of cell elongation - division cycle in Bacilli or DNA Repair Base Excision (EC 4.2.99.18)
Isozymes
Compare fitness of predicted isozymes for: 4.2.99.18
Use Curated BLAST to search for 4.2.99.18
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-positive bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (230 amino acids)
>BBR_RS13565 DNA-(apurinic or apyrimidinic site) lyase endonuclease III base excision repair (Bifidobacterium breve UCC2003) MATMNNRSAKRVPSVPSPAYIESLYRTMAAALGPTGWWPAETTFEIMVGAVLTQNTAWSN VNRSLAALNTEGVLEPHKLAIMGFEHLQELIRPSGFYVNKSKTVQSLSRWYVERCGASPE GAADIPDAELRTELLGLFGIGGETAGDLMLYVFSRRTFVADTYARRLFAFLGFDVPAGYP AFHRAYSPVVLDTSLSVKDLQEFHGLIDEFGKAYRDDAAKSESFLGGWRA