Protein Info for BBR_RS13445 in Bifidobacterium breve UCC2003

Annotation: phosphoribosylformylglycinamidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1244 TIGR01857: phosphoribosylformylglycinamidine synthase" amino acids 3 to 1242 (1240 residues), 2177.5 bits, see alignment E=0 PF18072: FGAR-AT_linker" amino acids 183 to 225 (43 residues), 39.1 bits, see alignment (E = 1.3e-13) PF02769: AIRS_C" amino acids 433 to 584 (152 residues), 89.2 bits, see alignment E=5.1e-29 PF13507: GATase_5" amino acids 979 to 1242 (264 residues), 274.8 bits, see alignment E=9.1e-86

Best Hits

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 98% identity to bll:BLJ_0583)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1244 amino acids)

>BBR_RS13445 phosphoribosylformylglycinamidine synthase (Bifidobacterium breve UCC2003)
MVFRVYVEKKPGFDVEAQQLAGELRTILGLTGLKALRIVNRYDVEGISQELFDQTVPTVF
SEPQVDNVAYDLPDFAGAKVFATEFLPGQFDQRADSAAECIQLISQGERPTVRSAKLYAL
EGELTDADVDTIEHYVINPVEAREASLETKETLKTQVPVPGKVETIAGFNEMDAEAGQKF
IDERGLAMDLADLEFCQKYFSEEGREPTITEIKVIDTYWSDHCRHTTFGTELDEVDIDDA
TVKAAFERYLEMRHELGRDAKPVCLMDMGTIGAKWLKKNGILTGLDESEEINACTVKVKV
DVNGENQDWLFLFKNETHNHPTEIEPFGGAATCIGGCIRDPLSGRSYVYQAMRVTGAADP
TVPVSETLEGKLPQRKLVTTAAAGYSSYGNQIGLATGQVDEIYHPGYVAKRMEVGAVVAA
TPADHVRRETPAPGDKIILLGGRTGRDGIGGATGASKAHNVESLELDGAEVQKGNAPVER
KLQRLFRRGDACRLIKRCNDFGAGGVSVAVGELADGLFVDLNTVPKKYEGLDGTELAISE
SQERMAVDVAAEDVDEFLTYAREENLEATVIATVTEDPRMVMTWNGDEIVNLSREFLASN
GASKHQTVHVEAQQGYETPWGEGTLAERMNKMVTDLNVASNKGLSERFDSTIGAGTVLMP
FGGKRQLTPNMAMVAKLPVFGETTTASAMAWGFNPYIMSKNQFTGAYLSVVESLAKLVAA
GFEHEKAYLSFQEYFEKLRDEPERWGKPTAAVLGALMAQVDLGAGAIGGKDSMSGSFEDL
DVPPTLISFAVAVGNMKRATSPEFKGDDHRIVRIAPRYLADGLTPDKDALLEAFSVIEEL
TDFHDALAVSTPGYGATAEALFKMTLGNRIGVTLNDSIAVDDLFTPAYGSFIVELADNAK
LPAVSNLVEIGEIGTTTSEYAFKAAGETLDLNAVQEAWESGIESVFPYRSKGEDKGKTVE
TIDFHAPKKTAYTGSSVAKPHVVIPVFPGNNCEYDSAAAFERAGADVTTLIVNNLTPAAV
AESTQALVEEINKSQIVMIPGGFSGGDEPDGSAKFITAFFRAPAVTEAVRDLLKNRDGLM
LGICNGFQALVKLGLVPYGDIVPMTDACPTLTFNTIGRHQSRLVRTRVASDLSPWLAKTS
VGDIHTVAISHGEGRFVASDEVLAQLKANGQIATQYVDETGTPGMDLDVNPNGSLLAIEG
ITSPDGRVFGKMGHSERSGNGLYVNVPGNKYQPIFEAGVEYFAA