Protein Info for BBR_RS13365 in Bifidobacterium breve UCC2003

Annotation: aldehyde dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 19 to 295 (277 residues), 191.9 bits, E=7.9e-61
  • amino acids 360 to 487 (128 residues), 84.3 bits, E=3.6e-28

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)

MetaCyc Pathways

• ethylene glycol degradation (2/2 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation II (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• putrescine degradation IV (2/3 steps found)
• putrescine degradation I (1/2 steps found)
• putrescine degradation V (1/2 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• ethanol degradation III (1/3 steps found)
• ethanol degradation IV (1/3 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• mitochondrial NADPH production (yeast) (2/5 steps found)
• octane oxidation (2/5 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (4/8 steps found)
• D-arabinose degradation II (1/4 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• putrescine degradation III (1/4 steps found)
• serotonin degradation (3/7 steps found)
• superpathway of glycol metabolism and degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• superpathway of ornithine degradation (2/8 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• aromatic biogenic amine degradation (bacteria) (1/8 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (1/11 steps found)
• superpathway of L-arginine and L-ornithine degradation (2/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• superpathway of pentose and pentitol degradation (4/42 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.3

Protein Sequence (519 amino acids)

>BBR_RS13365 aldehyde dehydrogenase family protein (Bifidobacterium breve UCC2003)
MTNETFEQLKVAYESGLTRPLAWRRAQLNALRRLVMENRDAFISSAMADLGKPAAETVLM
ELNLVAGEAQFVRNRLGLWTARHPKAMHWMLQPAAGWTIAEPKGVVLIISPWNYPVLLAL
EPMADALAAGNAVCLKPSELSPNTSKLLAELVPQYLDAEAVRVVEGGPKETGDLLKNPFN
HIFYTGGGRVGKIVMRAAAENLTPVTLELGGKSPCFVDRTADINVAARRIVWGKFTNAGQ
TCVAPDYVLATPDVAEALAKRIAVAVTEFYGKNPQDSPNFGRIINERHFDRLCKLLPVGT
VPSDEPSSPLIQVASAVGAAVDMVGKRINAAASGNTATEARPDTTETGIVAVPGVVDPAG
RVMCGGKVDRAARYVAPTVLYGTQPDAPVMGEEIFGPILPIVVVEDAEAAIRFINRRSRP
LAAYVFSRDHEVRLAFERQTSSGALGYSLPLGHLLSSRLPFGGVGGSGIGAYHGKEGFRT
FSHIKTVVSKPQFPDTLWLVYPPFNEAKAKLMDLISKLS