Protein Info for BBR_RS13285 in Bifidobacterium breve UCC2003

Annotation: 1-deoxy-D-xylulose-5-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF13292: DXP_synthase_N
  • amino acids 35 to 229 (195 residues), 238.4 bits, E=2.4e-74
• PF00456: Transketolase_N
  • amino acids 71 to 283 (213 residues), 33.2 bits, E=7.4e-12
• PF02775: TPP_enzyme_C
  • amino acids 139 to 275 (137 residues), 27.6 bits, E=5.9e-10
• PF02779: Transket_pyr
  • amino acids 351 to 489 (139 residues), 79.5 bits, E=6.2e-26
• PF02780: Transketolase_C
  • amino acids 550 to 675 (126 residues), 54.7 bits, E=2.5e-18

Predicted SEED Role

"1-deoxy-D-xylulose 5-phosphate synthase (EC 2.2.1.7)" in subsystem Isoprenoid Biosynthesis or Pyridoxin (Vitamin B6) Biosynthesis or Thiamin biosynthesis (EC 2.2.1.7)

MetaCyc Pathways

• superpathway of geranylgeranyl diphosphate biosynthesis II (via MEP) (11/12 steps found)
• taxadiene biosynthesis (engineered) (11/13 steps found)
• methylerythritol phosphate pathway I (8/9 steps found)
• methylerythritol phosphate pathway II (8/9 steps found)
• isoprene biosynthesis I (8/10 steps found)
• superpathway of thiamine diphosphate biosynthesis II (7/11 steps found)
• thiazole component of thiamine diphosphate biosynthesis II (4/7 steps found)
• superpathway of thiamine diphosphate biosynthesis I (6/10 steps found)
• thiazole component of thiamine diphosphate biosynthesis I (3/6 steps found)
• pyridoxal 5'-phosphate biosynthesis I (3/7 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (6/12 steps found)
• superpathway of ergosterol biosynthesis II (10/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Terpenoid biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.2.1.7

Protein Sequence (683 amino acids)

>BBR_RS13285 1-deoxy-D-xylulose-5-phosphate synthase (Bifidobacterium breve UCC2003)
MHSMPGNGISAHDASGATDNTHSPDSGNLADATLLRRITSPADVKALSPNTLNELCREIR
TTLLHYGHIHGGHIGSNLGMVEATVALHRVFDSPHDRIVFDVSHQSYVHKMLTGRAAAYL
DTNRFGDVTGFTNPDESDHDQFVLGHTGTSISLACGLAKTRNMEGPDSGIGNVVAVIGDG
SLSSGVAFEGLNNAAEQGGNLIIILNDNEMSIAGDFGGMYGTLARLRASGGTAQPNLFNA
FGLDYRYVEHGNDVDALVAAFEEVRNIDHPVVVHIHTLKGAGYDGEPTSSATGIHPSSNL
SHREPWHSDHCNLSDHEPHEGQCEASHWQNPDSAIGKPDDPRKYYGKMAMAALEPRFASE
PGLVVISPATPGSNGITHEFRERAGSHYVDTGITESHAVAFAAGIARAGGTPVVATTASF
FQRAYDQFFQEMSLNRSRVTVLDFLGGLSGSDNTHSGAYDVAMFANIPGITMLVPTSADE
YLADLAWATLPAGADGAPDGPVVIRVPGEAILAAEREPSLLPVTGGRVQVGHPQSTVSTA
PASGSDPLAWRINQTGSRVAIAGLGNAYPLAEQVAAALTAEHSMKATVIDPRQCTSLDAD
ALESLRDGHELVVTLEDGQLEGGWGEKVTAYYANHHVSDSSRNPRVLNFGAAKEFTDRVP
LGELNERYGLTVEQVTEAITRCF