Protein Info for BBR_RS13070 in Bifidobacterium breve UCC2003

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 630 (629 residues), 731.4 bits, E=4.1e-224
• PF13522: GATase_6
  • amino acids 74 to 202 (129 residues), 65 bits, E=1.1e-21
• PF13537: GATase_7
  • amino acids 90 to 212 (123 residues), 42.3 bits, E=1.1e-14
• PF01380: SIS
  • amino acids 310 to 431 (122 residues), 107.9 bits, E=5.1e-35
  • amino acids 480 to 610 (131 residues), 64.9 bits, E=9.7e-22

Best Hits

Swiss-Prot: 62% identical to GLMS_COREF: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 98% identity to bln:Blon_2018)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Protein Sequence (630 amino acids)

>BBR_RS13070 glutamine--fructose-6-phosphate transaminase (isomerizing) (Bifidobacterium breve UCC2003)
MCGIVGYAGNVETACGKPLEVCLQGLERLEYRGYDSAGVALTASGMDKVTVRKKAGRLKN
LVEDIECKPMPLATVGIGHTRWATNGEPSDVNAHPHTSMDGKVAIIHNGIIENASQLRLD
LQAEGYRFASATDTEVAAKLLGKIVDKIIAEEGKPNLFKAVRRMARMLEGAFTILATDCR
QPDIVVGARHDSPLVVGLGDGENFLGSDVAAFVAYTKRAMEVDQDQAVCVSADKVIVTDF
DGNVIENPKTYTVDWDASAAEKGGWDSFMDKEIHEDPAAVQRTLLGRFDPNGDITLDEVR
IDQHDFKAIDKIIVVACGTASYAGQVAKYAIEHWVRIPVEIELAHEFRYRDPILTPRTLV
VAISQSGETMDTLMALRHAREQGSKVLAICNTQGASIPRESDAVLYTHAGPEVAVASTKA
FVAQITAAYLLGLYLAQVKGAMFRDEIHQVLDSLKDMPRKIQWVLDTQPKTIQAAAERMV
NANSFLFLGRHVGYPVALEGALKLKEIAYTFTEGFAAGELKHGPIALVDEGEPVVFIVPP
ERGRNVLHAKVISGIEEVKARGAYIIAVAEQGDPDVERYADVVFWRPACPTLMSPLVDVV
PLQLFAMDMAKLKGYDVDKPRNLAKSVTVE