Protein Info for BBR_RS12905 in Bifidobacterium breve UCC2003

Annotation: galactose-1-phosphate uridylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 PF01087: GalP_UDP_transf" amino acids 73 to 239 (167 residues), 91.3 bits, see alignment E=1.1e-29 TIGR00209: galactose-1-phosphate uridylyltransferase" amino acids 74 to 412 (339 residues), 154.1 bits, see alignment E=2.5e-49 PF02744: GalP_UDP_tr_C" amino acids 248 to 364 (117 residues), 61.6 bits, see alignment E=7.9e-21

Best Hits

KEGG orthology group: K00965, UDPglucose--hexose-1-phosphate uridylyltransferase [EC: 2.7.7.12] (inferred from 99% identity to blb:BBMN68_977)

Predicted SEED Role

"Galactose-1-phosphate uridylyltransferase (EC 2.7.7.10)" in subsystem Lactose and Galactose Uptake and Utilization (EC 2.7.7.10)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.12

Use Curated BLAST to search for 2.7.7.10 or 2.7.7.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (416 amino acids)

>BBR_RS12905 galactose-1-phosphate uridylyltransferase (Bifidobacterium breve UCC2003)
MADFANYTPGEYAKKHIRITPTTLADGRDFFYLDDDPEFVSGAKTRELKDPRPLDYRFAP
HLDADGNEVPYAAPQMRRDPLTGDWIPMATARMNRPITAGPGATAKGNPLAARKPGDPYQ
DGEVPDTDYNVVVFENRFPSMVRVPGVSEDVTYVDGNPLWEKKLAAGRCEVICFDPNENG
LPADLPVSRLRTVVEAWAFRTAEISKMEGIEQIFPFENHGQEIGVSLAHPHGQVYCYPFI
APKMEKELQHTEAYHEKTGGNLLKDIMNAELEAGERIVMRNHSWVAYVPAAARWPLEVHV
APVRDVLTLDELNDEERWDLASMYSHLLKRGNAFFDKGDGKGMDLPYIAAWHQAPIHDAR
RENYRLNLQFFSFRRAANKIKYLAGSESGMAAWISDTTPELIAKRFHELGSIDIAD