Protein Info for BBR_RS12430 in Bifidobacterium breve UCC2003

Annotation: glucose-6-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00342: PGI
  • amino acids 56 to 557 (502 residues), 655.4 bits, E=2.6e-201

Best Hits

Swiss-Prot: 99% identical to G6PI_BIFLO: Glucose-6-phosphate isomerase (pgi) from Bifidobacterium longum (strain NCC 2705)

KEGG orthology group: K01810, glucose-6-phosphate isomerase [EC: 5.3.1.9] (inferred from 99% identity to blb:BBMN68_1041)

MetaCyc: 50% identical to glucose-6-phosphate isomerase (Escherichia coli K-12 substr. MG1655)
Glucose-6-phosphate isomerase. [EC: 5.3.1.9]

Predicted SEED Role

"Glucose-6-phosphate isomerase (EC 5.3.1.9)" in subsystem Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 5.3.1.9)

MetaCyc Pathways

• Bifidobacterium shunt (15/15 steps found)
• O-antigen building blocks biosynthesis (E. coli) (11/11 steps found)
• heterolactic fermentation (16/18 steps found)
• homolactic fermentation (11/12 steps found)
• glycolysis III (from glucose) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• sucrose degradation III (sucrose invertase) (4/4 steps found)
• sucrose degradation IV (sucrose phosphorylase) (4/4 steps found)
• glycolysis I (from glucose 6-phosphate) (10/13 steps found)
• sucrose degradation II (sucrose synthase) (4/5 steps found)
• superpathway of anaerobic sucrose degradation (14/19 steps found)
• sucrose biosynthesis II (6/8 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (12/17 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
• D-sorbitol biosynthesis I (1/3 steps found)
• sucrose biosynthesis III (1/3 steps found)
• glycolysis V (Pyrococcus) (6/10 steps found)
• starch biosynthesis (6/10 steps found)
• formaldehyde oxidation I (3/6 steps found)
• chitin biosynthesis (5/9 steps found)
• gluconeogenesis III (7/12 steps found)
• GDP-mannose biosynthesis (1/4 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• gluconeogenesis I (7/13 steps found)
• 1,3-propanediol biosynthesis (engineered) (4/9 steps found)
• 1,5-anhydrofructose degradation (1/5 steps found)
• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (15/26 steps found)
• colanic acid building blocks biosynthesis (4/11 steps found)
• gluconeogenesis II (Methanobacterium thermoautotrophicum) (7/18 steps found)
• superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (3/14 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• Methanobacterium thermoautotrophicum biosynthetic metabolism (16/56 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Glycolysis / Gluconeogenesis
• Pentose phosphate pathway
• Starch and sucrose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.9

Protein Sequence (566 amino acids)

>BBR_RS12430 glucose-6-phosphate isomerase (Bifidobacterium breve UCC2003)
MAINPPVDATQTPEWAALQKHYDELQSEGVSLKKWFADDAERVDKLSFDAGDLHFDLSKN
LIKPETLQLFANLAKAVKLDERTKAMYSGVHINNTEDRAVLHTALRRPVEDEGKYIVDGQ
DTVKDVRETLDKIYAFADDVRSGKWTGVTGRKIETVVNIGIGGSDLGPVMVYEALKPYAD
AGISARYISNIDPNDLAEKTKGLDPETTLFIIVSKTFTTLETLTNAREARTWLLEELAAN
GAIAEGDEAQKAEAIKKHFVAVSTNLEKVEEFGIDPNNAFGFWNWVGGRYSVDSAVGTSL
AVVFGPARFEEFLHGFHEIDEYFANTPFEKNVVVLLGMLNVWYRNFFKVASHAVLPYDQY
LHRFPAYLQQLTMESNGKSVRWDGTPVTSETGEIFWGEPGTNGQHAFYQLIHQGTQLIPA
DFIAFVNTPNPTKDGDQDVHELFLGNYFAQTKALAFGKTADEVRAEGTPEEIVPARVFSG
NRPTTSIFGVALTPFALGELIALYEHITFVEGTVWGLDSYDQWGVELGKQLAKQITPAIS
QDDEALAAQDASTQSLIKFYRANREF