Protein Info for BBR_RS12110 in Bifidobacterium breve UCC2003

Annotation: CPBP family intramembrane metalloprotease domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 345 transmembrane" amino acids 32 to 53 (22 residues), see Phobius details amino acids 68 to 90 (23 residues), see Phobius details amino acids 110 to 132 (23 residues), see Phobius details amino acids 152 to 170 (19 residues), see Phobius details amino acids 190 to 218 (29 residues), see Phobius details amino acids 225 to 246 (22 residues), see Phobius details amino acids 278 to 299 (22 residues), see Phobius details amino acids 324 to 344 (21 residues), see Phobius details PF02517: Rce1-like" amino acids 150 to 236 (87 residues), 80 bits, see alignment E=6.6e-27

Best Hits

KEGG orthology group: None (inferred from 74% identity to blm:BLLJ_0273)

Predicted SEED Role

"FIG00672090: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (345 amino acids)

>BBR_RS12110 CPBP family intramembrane metalloprotease domain-containing protein (Bifidobacterium breve UCC2003)
MSKPQTSQTEQGTQTTLPQQSGNWWFVAYRRFSIVGVALAIMVAFWIGLNMLATGALHQF
AGNDVPTWAVLLASSGPLYLVAMPLSMLVFTRVPAISTRQFAMKPGEFIPLFIICIPVMY
LGNIIGMVLSAGVTDGQATNRINDLVLGGNEWVNALFVGLLAPICEEWLFRKQIISRLRR
YGEKTAIVFSALAFALFHMNLFQFFYAFGLGLIFGYVYTRTSRLRYSVLMHMLINLNGSV
LAPLMLKQIDPRILSGTISEAEIMSMVQGGSGMRGLSIMMLYGMVMLGLLIAGIVLLIVK
RRNWEFYLAPEELPTGLKVRTTYGNPGVVIYILLTVGLTIWMLLA