Protein Info for BBR_RS11745 in Bifidobacterium breve UCC2003

Annotation: glycoside hydrolase family 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 PF02837: Glyco_hydro_2_N" amino acids 18 to 188 (171 residues), 69.1 bits, see alignment E=6.9e-23 PF00703: Glyco_hydro_2" amino acids 194 to 296 (103 residues), 50.8 bits, see alignment E=4.1e-17 PF02836: Glyco_hydro_2_C" amino acids 305 to 527 (223 residues), 38.6 bits, see alignment E=1.1e-13

Best Hits

KEGG orthology group: None (inferred from 100% identity to bln:Blon_0268)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (606 amino acids)

>BBR_RS11745 glycoside hydrolase family 2 (Bifidobacterium breve UCC2003)
MERIQYPDPQCVRRNWVDLNGTWDFAIPGAPAGTKNGNQGNNAMESTPETLQAAASMAFP
EFDRTIEVPYSYTFPKSGVDEPQYHPVVWYRRSFDLDMRPGKRYLLNFEAVDYACDVWLN
GRHVGSHQGGHTPFRFDVTPYAAKENELVVKVVDFNRTDQPLGKQAWKDGNFACWYTRTI
GIWQSVWLEETGDVHLTDFTMTPHANQARLDVDASLNVNVDAELDYNVTFEGKPVTHGTV
SFTNARARFSVEIRNYDPSPEPHPWTPSTPDLYDIDFTVRSGGETTDEVSSYFGLRDVTS
DGKMIFLNDQKYYMKLLLNQGYYPGGGLTGTADEFRADIEKMKAMGFNGNRIHQKLESNR
MLYLCDKLGFIVWAEMPSAYEFGPELIANVERELPAYLRKHVNHPSVFAYVLMNESWGVF
DIAHSEQERTFVNSLYYQAKAFDPSRLVIGNDGYEQTRTDIATIHDYNADADELLETYQG
RRDEVLAGAPSPMGGRRVFCQGYEQQRVPVMVTEYGGVAYEPGGHTEDSWGYGERITDPD
KVVDQIAALTRAVMDIDYCVGFCYTQTSDVEQEVNGLLDHDHEYKFDPKRIREVLLSKHT
YGYVQV