Protein Info for BBR_RS11660 in Bifidobacterium breve UCC2003

Annotation: YHS domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 878 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 206 to 229 (24 residues), see Phobius details amino acids 241 to 263 (23 residues), see Phobius details amino acids 270 to 288 (19 residues), see Phobius details amino acids 436 to 455 (20 residues), see Phobius details amino acids 461 to 483 (23 residues), see Phobius details amino acids 687 to 706 (20 residues), see Phobius details amino acids 712 to 732 (21 residues), see Phobius details PF13473: Cupredoxin_1" amino acids 25 to 125 (101 residues), 61.8 bits, see alignment E=1.7e-20 TIGR01494: HAD ATPase, P-type, family IC" amino acids 278 to 533 (256 residues), 129.8 bits, see alignment E=1.5e-41 amino acids 543 to 705 (163 residues), 105.1 bits, see alignment E=4.7e-34 PF00122: E1-E2_ATPase" amino acids 320 to 496 (177 residues), 175.3 bits, see alignment E=2.9e-55 PF12710: HAD" amino acids 532 to 637 (106 residues), 31.2 bits, see alignment E=8.8e-11 PF00702: Hydrolase" amino acids 536 to 641 (106 residues), 64.2 bits, see alignment E=6.7e-21 PF04945: YHS" amino acids 833 to 877 (45 residues), 40 bits, see alignment 9.3e-14

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 88% identity to bll:BLJ_0241)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (878 amino acids)

>BBR_RS11660 YHS domain-containing protein (Bifidobacterium breve UCC2003)
MEFNLFSTAAALIAAAALTWLVLRFFFGAQKAASGAMDASGKRQTATITVKGGYSPAVVS
MRAGTPITLTFDRQETGECTSHVVFGDLGLDAMLPGNAVTDVELPALPAGEYPFACGMNM
VHGLLKVEGNASAGTDKLYPLTASAEAPMLDSAEAERREAAERTKEITSLTRLVAIGTVL
TLPVFIVTMLHMANSMLVPHWMVNPWLQAILITPVMFYCGHPIHAVGFPALAHRSPDMNS
LVSLGTSAAYLYSLVTCVAPQVFPEGSREPYFESVGVVITLVLVGRLLETKAREGTGKAV
QSLIKLRPRTAHKLNAASPENVEWLNPANFTDMDIDTIAVGDLLVVKNGERVPTDGIIVA
GNASIDESMITGESKPVTKTTGAAVTGATVLLKGDLVMQATQVGANTVLSQIAAMVARAQ
ATKAPVQQLADRIARYFVPAVMVIAIWTFAIWIALGPAPQLAHALITAVSVLIIACPCAL
GLATPLSVTVSLGLGATNGVLVTSAKALEQARRIGTVIFDKTGTITRGVVDATADWNKPS
YEQDTVKEGSPEAIAALRARGIRTVMLSGDKAEVAGRIAREVGIDTVICEVKPDGKAYWI
AKLQRERDENTATSGSSRAPHDLIAMVGDGINDAPALAQADLGIAIGTGTDVAMQSADVT
LMSGDLRGVIRTINLSNATMRNIRENLGWAFGYNIIGIPIAAGVLYPFTGWLLSPMIAGL
AMALSSVCLVLNANRLHAANINVGAADSTAGSGSSTAGIESAGSAESANAANATGSTTSN
APHEPTVIIDDRTTLNHTNHVSDQSNNPTNKENTMDMGMHMHHNAPAGGETATDPVCGMT
VAVNADAITREYEGKSYYFCGEHCATNFMKAPQVFLEQ