Protein Info for BBR_RS11190 in Bifidobacterium breve UCC2003

Annotation: dTMP kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00041: dTMP kinase
  • amino acids 2 to 198 (197 residues), 175.3 bits, E=6e-56
• PF02223: Thymidylate_kin
  • amino acids 8 to 198 (191 residues), 169.8 bits, E=2.8e-54

Best Hits

Swiss-Prot: 95% identical to KTHY_BIFLD: Thymidylate kinase (tmk) from Bifidobacterium longum (strain DJO10A)

KEGG orthology group: K00943, dTMP kinase [EC: 2.7.4.9] (inferred from 95% identity to blm:BLLJ_0153)

MetaCyc: 39% identical to Tmk (Escherichia coli K-12 substr. MG1655)
T(2)-induced deoxynucleotide kinase. [EC: 2.7.4.12, 2.7.4.13, 2.7.4.9]

Predicted SEED Role

"Thymidylate kinase (EC 2.7.4.9)" (EC 2.7.4.9)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (13/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (6/9 steps found)
• pyrimidine deoxyribonucleotide phosphorylation (2/4 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis II (4/7 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (4/7 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (9/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (5/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (4/8 steps found)
• purine deoxyribonucleosides salvage (2/6 steps found)
• superpathway of pyrimidine deoxyribonucleoside salvage (4/9 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.12 or 2.7.4.13 or 2.7.4.9

Protein Sequence (206 amino acids)

>BBR_RS11190 dTMP kinase (Bifidobacterium breve UCC2003)
MSGLFVSFEGVDGVGKTTQVERLRAYLEAQGRTVVVTREPGGTALGKAVRQLLLHGVNEG
ADDIAPRAEALLFAADRAQHVAETIRPALERGEVVITDRYLDSSLAYQAGGRELTSEEIR
SLSMWATNNLLPDRTYLLDMDPTLSHNRLEHAEDRMESAGDDFQSRTRQAFLDLAAVEPN
RFRVIDASQSIEQVWAAIEADIKELA