Protein Info for BBR_RS10985 in Bifidobacterium breve UCC2003

Annotation: DNA polymerase III subunit gamma and tau

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 910 TIGR02397: DNA polymerase III, subunit gamma and tau" amino acids 4 to 362 (359 residues), 373.8 bits, see alignment E=4.9e-116 PF13177: DNA_pol3_delta2" amino acids 20 to 177 (158 residues), 129.2 bits, see alignment E=2.4e-41 PF00004: AAA" amino acids 41 to 171 (131 residues), 39.5 bits, see alignment E=1.1e-13 PF12169: DNA_pol3_gamma3" amino acids 235 to 365 (131 residues), 34.8 bits, see alignment E=2.1e-12

Best Hits

KEGG orthology group: K02343, DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] (inferred from 74% identity to blj:BLD_1289)

Predicted SEED Role

"DNA polymerase III subunits gamma and tau (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (910 amino acids)

>BBR_RS10985 DNA polymerase III subunit gamma and tau (Bifidobacterium breve UCC2003)
MALALYRRYRPDTFEGVIGQDQVTVPLMRALDEGRLTHAYLFSGPRGCGKTSSARILARC
VNCAKGPTSHPCGECESCKDLATGGPGSIDVVEIDAASHNGVDDARELRERAGFAPARDR
YKIFILDEAHMVTQQGFNALLKIVEEPPEHVMFIFATTEPDKVIGTIRSRTHHYPFRLVP
QEVMGPYLETICEKESIKPEPGVLKLAMRAGGGSMRDTLSVLDQLMVGSVEGVITHDAAV
ALLGFTPEALIGEAIDAVIDHNGEALYGVIQKVVVGGFDPRRFVEDLLARVRDLLVLTLA
GDRAESVLSDTAEAEDMDDLHRQAKALGLSALTAIADIINTTLGAMTGAISPRMRLELLA
ARLLAGSENGFVAPAAAPALGAPAPATGAVASAAPATGGAAGGFAGASRGGFAGASQGGF
SGASRNRSQSQPQTPANAPAANAGGWNAAGTLNPAGSAGQTGAAGQAAPAQQAMPAAAAP
AAPASPATNAAAPSSDSRSTDEKWNAAVAALPQAIREYVTRDKVPTVAFGPNRKGLPCLS
MTFDKPLSQHAFALAVDNSGKKAAIVVMDAVRQEFGADAVIAPAAVAANGERVESVKRLS
PEQLAKVKQQIAMAKAGLAASSLGAGLGMHSGSEPKAQKPAAEGNAEDADGSHRASGVTP
GGTSNKPDLDDDDPWAKPAASSEAVGEPSASAGEPSVDGFAPSNPDPASAQAPEEHHKKH
VAVPDMSDDVDPWATPAAPVAHAQDATANTQAGQAEQSAASTSSNVGAPAADSAAPTASA
DPWNQPAASAPQAAPDPWNQPAPPQSEPDPWNQPQGQAQRQTPSQSQGIPQSQNSGAADP
WNQSVPPSPQPQVAAEDDEYSMSDQSLGDATAMKMDDLKKLFEVKKVEEFAADDPKNPKN
IQPAKKHTDD