Protein Info for BBR_RS10775 in Bifidobacterium breve UCC2003

Annotation: LacI family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 361 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00356: LacI" amino acids 4 to 48 (45 residues), 68 bits, see alignment 7.2e-23 PF00532: Peripla_BP_1" amino acids 61 to 184 (124 residues), 52.3 bits, see alignment E=9.1e-18 PF13377: Peripla_BP_3" amino acids 166 to 338 (173 residues), 40.4 bits, see alignment E=5.4e-14

Best Hits

KEGG orthology group: K03484, LacI family transcriptional regulator, sucrose operon repressor (inferred from 98% identity to blj:BLD_1342)

Predicted SEED Role

"Sucrose operon repressor ScrR, LacI family" in subsystem Sucrose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (361 amino acids)

>BBR_RS10775 LacI family transcriptional regulator (Bifidobacterium breve UCC2003)
MVGMRDVAKKAGVSLSTVSLVVNGNGYVSDDMRERVRKAMQLLNYVPNELARNLYHDRTN
LVGVIVPTIRHPFFATFTAHLQHALAAQGLRTMLCSTADEADGEIQYVDMLRRHMMDGIV
MCAHTSHPGDYWTSIHRPIVAFDRVLGDGISSIGSDHEQGGRLIAQMLIRNGAKHVVMIG
GPRDQFFDLAARGEVEEGPFDLGKTTFPTVRYYLTLEQELTSAGVKYEYVEAGEVMDFAG
YHRAVSNALDKVTTDGVDAVVSSDIGASFCVREALSRGIAIPDELQIVAYDGTYLTDLAG
MKLTAVAQDFSAIAQSTADHIVQAIANEEVAAANASRRDIPKPFEPNVLIPMTLVPGDTT
R