Protein Info for BBR_RS10535 in Bifidobacterium breve UCC2003

Annotation: sodium/proline symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 58 to 82 (25 residues), see Phobius details amino acids 116 to 140 (25 residues), see Phobius details amino acids 152 to 173 (22 residues), see Phobius details amino acids 184 to 204 (21 residues), see Phobius details amino acids 250 to 268 (19 residues), see Phobius details amino acids 289 to 313 (25 residues), see Phobius details amino acids 326 to 350 (25 residues), see Phobius details amino acids 385 to 404 (20 residues), see Phobius details amino acids 415 to 435 (21 residues), see Phobius details amino acids 442 to 460 (19 residues), see Phobius details amino acids 467 to 491 (25 residues), see Phobius details PF00474: SSF" amino acids 26 to 450 (425 residues), 260.3 bits, see alignment E=1.6e-81 TIGR00813: transporter, solute:sodium symporter (SSS) family" amino acids 26 to 450 (425 residues), 245.9 bits, see alignment E=4.2e-77

Best Hits

KEGG orthology group: K11928, sodium/proline symporter (inferred from 97% identity to blb:BBMN68_1331)

Predicted SEED Role

"Proline/sodium symporter PutP (TC 2.A.21.2.1) @ Propionate/sodium symporter" (TC 2.A.21.2.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-positive bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (536 amino acids)

>BBR_RS10535 sodium/proline symporter (Bifidobacterium breve UCC2003)
MVIYFAAMLSIGFIYSKRSNSSSKEYFAGGRGVGPWLTALSAEASDMSGWLLMGLPGLAY
FTGAADPMWTAIGLALGTYLNWKLVARRLRRYSVVAGDAITIPDFFAKRFHDEKGVISTI
AAVIILVFFSVYVGSCFVTVGKLFATLFGFDYHIMMIIGAVVVFVYTVVGGYLSVVMTDF
IQGMLMFFALAVVFIGTVASAGGIDNTVEFLRSIPGYLSGTQVAAPKLDPATGQQLVEAG
KAVFGAPSDYGIITIISMLAWGLGYFGMPQVLVRFLSIRSVEEVRKSQIIATSWCVISLG
CAVCIGLVGRAMMPTGLLTSTDAETIFIVLAQTLLPSFMCGVVVSGIFAASMSSSSSYLI
IGASAMGENIFRGLLHKKATDRQVMIVARVTLVVMFLFGIVVAFDQNSSIFQVVSYAWAG
LGASFGPLMLCSLYWRRANKAGAVAGMLSGTATVLIWHNLVKPLGGVFAIYELLPAFIIS
LLFIVVVSLLTAKPNERMLYEFDHYMDDPLPGTLPSGTVLVDEPMEAMEAEVRSGK