Protein Info for Ac3H11_966 in Acidovorax sp. GW101-3H11

Annotation: Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 848 transmembrane" amino acids 151 to 170 (20 residues), see Phobius details amino acids 190 to 212 (23 residues), see Phobius details amino acids 224 to 240 (17 residues), see Phobius details amino acids 252 to 270 (19 residues), see Phobius details amino acids 406 to 426 (21 residues), see Phobius details amino acids 432 to 458 (27 residues), see Phobius details amino acids 757 to 773 (17 residues), see Phobius details amino acids 779 to 798 (20 residues), see Phobius details PF00403: HMA" amino acids 73 to 130 (58 residues), 42.7 bits, see alignment 9.1e-15 TIGR01525: heavy metal translocating P-type ATPase" amino acids 222 to 799 (578 residues), 473.7 bits, see alignment E=1.9e-145 PF00122: E1-E2_ATPase" amino acids 290 to 467 (178 residues), 149.7 bits, see alignment E=1e-47 TIGR01494: HAD ATPase, P-type, family IC" amino acids 303 to 514 (212 residues), 119.1 bits, see alignment E=3.7e-38 amino acids 628 to 777 (150 residues), 98 bits, see alignment E=9.3e-32 PF00702: Hydrolase" amino acids 483 to 710 (228 residues), 78.6 bits, see alignment E=1.3e-25

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 81% identity to vei:Veis_1172)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165JTA5 at UniProt or InterPro

Protein Sequence (848 amino acids)

>Ac3H11_966 Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4) (Acidovorax sp. GW101-3H11)
MFRPDASVASPAHLPDGMADSSPAAPTQLLDDPQEWLAFGRPCTPAGSPLPAHALEAVQA
CPEASTWDSHVVLEGMHCAACALTIEDALRAVPGVLQADVSAATRRARVVWQPGRVLPSQ
WMKAVQNAGYRAMPAMDAFARAQRQRESRRALWRWLVAGFCMMQVMMYAWPAYVAQPGDL
SGEMEQLLRWASWVITLPMVVFSCGPFFASALRDVRLRRVSMDLPVALGMAITFVVSTAG
TFDPSGIFGKEVYYDSLTMFVFFLLTGRWLELRLRDRTAGALEAVMNRLPDSVERRDNAT
GTFARVATRRLVVGDTIRVLPGEAFPADGCITAGNTHADEALLTGESTPVARPLGSHVTA
GSYNLQSPVEVRVEGTGGQTRFAQIVALMESASLQKPRLALLADRIARPFLVAVLLAAGL
AAAWWWPSDPGHALMVAVAVLIVTCPCALSLATPVAMLTAAGTLARHGVLVRNLQGLEAL
AQVDTLVFDKTGTLTRDGMALQAVHTARGWAADDVLGLAAALARHSMHPASRAVVAAASA
SVPAPQGRWRVANLQEDAGLGLSAAVSDNTGVVPDCKVWLGSARHAGVAAQQGTAALQVV
LSAQGVEQGLEQESEGALLELARFDLVEDLRSEAPAVVATLQQEGVAVQLLSGDRLGAVQ
RVAAQAGIAQVQGECSPHGKLEALRALQAGGHQVAMVGDGLNDGPVLAGAHVSFAFGRAV
PLAQSRADFVVLGDSLALVPQTVLLARRTLRVVRQNLWWAAGYNALCVPLAVAGWMPAWL
AGLGMALSSLLVVLNAARLARGLPVLPALAGVDAGADAGMDAEALAAGKAQQAPLPLPNL
PKTTLEPV