Protein Info for Ac3H11_921 in Acidovorax sp. GW101-3H11

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 776 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 34 to 52 (19 residues), see Phobius details amino acids 64 to 85 (22 residues), see Phobius details amino acids 99 to 118 (20 residues), see Phobius details amino acids 130 to 150 (21 residues), see Phobius details amino acids 157 to 181 (25 residues), see Phobius details amino acids 192 to 209 (18 residues), see Phobius details amino acids 221 to 239 (19 residues), see Phobius details amino acids 260 to 281 (22 residues), see Phobius details amino acids 287 to 310 (24 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 334 to 499 (166 residues), 109.1 bits, see alignment E=9.7e-36 PF00990: GGDEF" amino acids 336 to 497 (162 residues), 132.9 bits, see alignment E=9.1e-43 PF00563: EAL" amino acids 518 to 748 (231 residues), 224.8 bits, see alignment E=1.1e-70

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165JSB4 at UniProt or InterPro

Protein Sequence (776 amino acids)

>Ac3H11_921 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Acidovorax sp. GW101-3H11)
MPFAERALTAVWLGAALLLFGASLWVQDASLRLFLDNASWTLAFGLSAFWAWRGRAQVPP
AQRLLHTGLWVGTVLVLAGQLVWNLQVALDWNPFPAPADLFFLSVGPLWAATVIRATFAR
LSKDRAYPAALDFGGAVLALLAFTLVIYLPSGQDQPLAVATVLLLYPAVYLTAAGVTALA
MPTVGVRVTRAHLLVLAGMLGYGLSWMQWNLMLLGGTVQPGMLFNASFSLAALALGWGAR
GLRFEVSDDPDYRRRCDQAMNYVPLVAMGLAGVTLVRLFIITPDGRAGVQALILVCCLLV
LLLAALRQAIVVGLLNRLRTAEAAVLRNEERLYHVAHFDALTGLPNRRYFEDALERAVAE
AGRYTQAPDRCVALLLIDLDHFKSVNETYGHRVGDALLSEVAQRIHQLLEGQWLVSRLAN
DQFTVMLQRPASRTVLAQLATTLLEGLARPWELSEVGAQYMGASIGISLFPDDASNSVEL
VRHAHSALHATKSAGRGSYRFYIEEFTHATRTRLELRRRLHGALQGGEFTLVYQPQLNHL
RQTVGAEALLRWSVDGKPVPPDEFIPLAEESGLIVPMGLWVFETACRQVAQWRAEGWQVP
VVSVNVSTIQLREPGFAQALLGIAQRAGVAPASLVLEITESQLLDESLYAMALDLKNAGF
VLSIDDFGTGHSSLVKLKRLPVSELKIDKEFVRDIVVDPNDREICATVNALARALGLEVV
AEGVETEAQWQLLVKMGCQRFQGWLFAPALAPEDLAQHWLQPVAAGSLAPVIKNDS