Protein Info for Ac3H11_82 in Acidovorax sp. GW101-3H11

Annotation: Methionine aminopeptidase (EC 3.4.11.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00500: methionine aminopeptidase, type I
  • amino acids 9 to 255 (247 residues), 310 bits, E=6e-97
• PF00557: Peptidase_M24
  • amino acids 20 to 247 (228 residues), 173.4 bits, E=2.8e-55

Best Hits

Swiss-Prot: 58% identical to MAP1_ECOL6: Methionine aminopeptidase (map) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K01265, methionyl aminopeptidase [EC: 3.4.11.18] (inferred from 82% identity to vpe:Varpa_4894)

MetaCyc: 58% identical to methionine aminopeptidase (Escherichia coli K-12 substr. MG1655)
Methionyl aminopeptidase. [EC: 3.4.11.18]

Predicted SEED Role

"Methionine aminopeptidase (EC 3.4.11.18)" (EC 3.4.11.18)

MetaCyc Pathways

• Arg/N-end rule pathway (eukaryotic) (8/14 steps found)
• Ac/N-end rule pathway (6/21 steps found)

Isozymes

Compare fitness of predicted isozymes for: 3.4.11.18

Use Curated BLAST to search for 3.4.11.18

Sequence Analysis Tools

See A0A165HZV4 at UniProt or InterPro

Protein Sequence (266 amino acids)

>Ac3H11_82 Methionine aminopeptidase (EC 3.4.11.18) (Acidovorax sp. GW101-3H11)
MARADRGVPIRSAEELVMARRAAQLAAEVLAMIEPHVVPGVTTDALDRLCHDHIVNVQGA
RPANVGYLGYPKTVLTSVNHVVCHGIPSPQQMLKKGDIVNIDVAVEKDGWYGDTSRMFCV
GTPSVLAQRLVRTTYEALCAGIRTVKPGATLGDVGHAIATVAQRENFSVVREYCGHGIGT
VYHDEPQVLHYGRRGQGLRLEAGMVFTIEPMLNAGQHETKELADGWTVVTKDRSLSAQWE
HMVAVTDSGYEVLTAWPGGTGAYAPV