Protein Info for Ac3H11_749 in Acidovorax sp. GW101-3H11

Annotation: Thiamine-monophosphate kinase (EC 2.7.4.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01379: thiamine-phosphate kinase
  • amino acids 2 to 323 (322 residues), 318.4 bits, E=2.2e-99
• PF00586: AIRS
  • amino acids 23 to 133 (111 residues), 106.9 bits, E=8.2e-35
• PF02769: AIRS_C
  • amino acids 145 to 306 (162 residues), 39.4 bits, E=7.2e-14

Best Hits

KEGG orthology group: K00946, thiamine-monophosphate kinase [EC: 2.7.4.16] (inferred from 81% identity to vei:Veis_0583)

Predicted SEED Role

"Thiamine-monophosphate kinase (EC 2.7.4.16)" in subsystem Thiamin biosynthesis (EC 2.7.4.16)

MetaCyc Pathways

• superpathway of thiamine diphosphate biosynthesis II (10/11 steps found)
• superpathway of thiamine diphosphate biosynthesis I (8/10 steps found)
• thiamine diphosphate biosynthesis I (E. coli) (2/2 steps found)
• thiamine diphosphate biosynthesis II (Bacillus) (2/2 steps found)
• thiamine diphosphate salvage II (4/5 steps found)
• thiamine diphosphate salvage V (2/3 steps found)
• thiamine diphosphate salvage I (1/2 steps found)

KEGG Metabolic Maps

• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.16

Sequence Analysis Tools

See A0A165JBT4 at UniProt or InterPro

Protein Sequence (324 amino acids)

>Ac3H11_749 Thiamine-monophosphate kinase (EC 2.7.4.16) (Acidovorax sp. GW101-3H11)
MGEFDLIARYFTRPVRRAALGVGDDCALLAPAPGMQLAISSDMLVEGRHFFADVDPEALG
HKALAVNLSDLAACGARPLAFTLALSLPRVDEAWLAGFSRGLLALADAHGCELVGGDTTQ
GPLNLCITVFGEVPTGQALLRSGARPGDDLYVSGTLGDARLALEALLGHRPLPAEVLARA
RQRLERPTPRVALGQALRGIASSAMDLSDGLLGDLSHILKASGVGARIDTHKTSNLIAEK
AYLSRGEGHFDLELIRQCTLAGGDDYELAFTAPPARRDAVAAASQASGTPVTRIGTVLAE
PGLQLVDAQGQAVEHRYASFDHFR