Protein Info for Ac3H11_689 in Acidovorax sp. GW101-3H11

Annotation: Leucyl-tRNA synthetase (EC 6.1.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 907 TIGR00396: leucine--tRNA ligase" amino acids 6 to 907 (902 residues), 1015.5 bits, see alignment E=0 PF00133: tRNA-synt_1" amino acids 15 to 597 (583 residues), 128.2 bits, see alignment E=7.4e-41 amino acids 655 to 688 (34 residues), 24 bits, see alignment (E = 3.2e-09) PF09334: tRNA-synt_1g" amino acids 38 to 171 (134 residues), 68.2 bits, see alignment E=1.2e-22 PF13603: tRNA-synt_1_2" amino acids 223 to 416 (194 residues), 217.7 bits, see alignment E=1.9e-68 PF08264: Anticodon_1" amino acids 746 to 870 (125 residues), 55.5 bits, see alignment E=1.3e-18

Best Hits

Swiss-Prot: 87% identical to SYL_ACIAC: Leucine--tRNA ligase (leuS) from Acidovorax citrulli (strain AAC00-1)

KEGG orthology group: K01869, leucyl-tRNA synthetase [EC: 6.1.1.4] (inferred from 87% identity to aav:Aave_4548)

Predicted SEED Role

"Leucyl-tRNA synthetase (EC 6.1.1.4)" (EC 6.1.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165JWG7 at UniProt or InterPro

Protein Sequence (907 amino acids)

>Ac3H11_689 Leucyl-tRNA synthetase (EC 6.1.1.4) (Acidovorax sp. GW101-3H11)
MQDKYSPQDVERAAHDHWTATDAYRVTEDTSKKKFYACSMLPYPSGKLHMGHVRNYTIND
MLTRYLRMNGHNVLMPMGWDAFGLPAENAALKNGVPPAKWTYENIAYMKKQMQAMGLAID
WSREVATCDPEYYKWNQWLFLKMLEKGIAYRKTQVVNWDPVDQTVLANEQVIDGKGWRTG
ATVEKREIPGYYLKITDYAEELLGFVTGDKLPGWPERVKLMQENWIGKSEGVRFAFTHDI
AGDDGTLIGDGKMYVFTTRADTIMGVTFCAVAPEHPLAAHAAKTNPALQAFIEECKSGGT
TEAELATQEKKGVPTGLYVTHPLTDEKVEVWVGNYVLMGYGDGAVMGVPAHDERDFAFAL
KYGIEIKQVVLVDGETFNYHQWQDWYGDKQRGVTINSDSFSGLSYKEAVNAVAHALEQKG
LGEKKTTWRLRDWGVSRQRYWGTPIPIIHCDEHGAVPVPEKDLPVVLPQDCIPDGSGNPL
HKHEGFHAGVTCPVCGKPARRETDTMDTFVDSSWYFMRYCDPKNADAMVADGTAYWMRDQ
QHATGGSGMDQYIGGIEHAILHLLYARFWTKVMRDLGLVKVDEPFTKLLTQGMVLNHIYS
RRTAKGGKDYFWPHDVEHVLDEGGKIIGAKLKNEATSGDGMQPVGTPIDYEGVGTMSKSK
NNGVDPQDLIEKYGADTARLYTMFTAPPEATLEWNDAAVEGSYRFLRRVWNFGVKLSAID
RDAALASVAGASSLQDVQFGKEAKALRLEIHNVLKQVDYDYQRMQYNTVVSGAMKMINAL
EDFKATDSAGAQVALIEGFGILLRSLYPATPHIAHSLWTGLGYAGALGDLLDAPWPQIDA
GALVQDEIELMLQVNGKLRGSIHVPAQADKAEIERIALASEAFVAQAAGAHPKRVIVVPG
RLVNVVV