Protein Info for Ac3H11_509 in Acidovorax sp. GW101-3H11

Annotation: Inorganic pyrophosphatase (EC 3.6.1.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00719: Pyrophosphatase
  • amino acids 18 to 174 (157 residues), 197.8 bits, E=4.5e-63

Best Hits

Swiss-Prot: 67% identical to IPYR_ECOLI: Inorganic pyrophosphatase (ppa) from Escherichia coli (strain K12)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 85% identity to vap:Vapar_2358)

MetaCyc: 67% identical to inorganic pyrophosphatase (Escherichia coli K-12 substr. MG1655)
Triphosphatase. [EC: 3.6.1.25]; Inorganic diphosphatase. [EC: 3.6.1.25, 3.6.1.1]

Predicted SEED Role

"Inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

• glyphosate degradation III (4/7 steps found)
• (aminomethyl)phosphonate degradation (3/8 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1 or 3.6.1.25

Sequence Analysis Tools

See A0A165LIL7 at UniProt or InterPro

Protein Sequence (178 amino acids)

>Ac3H11_509 Inorganic pyrophosphatase (EC 3.6.1.1) (Acidovorax sp. GW101-3H11)
MSLNNVTPGKNIPEAFNVVIEIPMNADPIKYEVDKESGAIFVDRFMTTAMHYPTNYGYVP
QTLSGDGDPVDVLVITPYPLHPGVVVPCRPLGILMMEDEAGVDGKVIAVPTSKILPMYDH
WKDIDDVNAMRRNAIAHFFEHYKDLEKGKWVKVLGWEGIESAKKEVVDGIESYKKSQA