Protein Info for Ac3H11_4733 in Acidovorax sp. GW101-3H11

Annotation: Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00735: imidazoleglycerol phosphate synthase, cyclase subunit
  • amino acids 1 to 249 (249 residues), 337.2 bits, E=2.7e-105
• PF00977: His_biosynth
  • amino acids 2 to 233 (232 residues), 257.8 bits, E=8.3e-81

Best Hits

Swiss-Prot: 90% identical to HIS6_ACIAC: Imidazole glycerol phosphate synthase subunit HisF (hisF) from Acidovorax citrulli (strain AAC00-1)

KEGG orthology group: K02500, cyclase [EC: 4.1.3.-] (inferred from 91% identity to aaa:Acav_1018)

Predicted SEED Role

"Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)" in subsystem Histidine Biosynthesis (EC 4.1.3.-)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Pyruvate metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.-

Use Curated BLAST to search for 4.1.3.-

Sequence Analysis Tools

See A0A165L7Y5 at UniProt or InterPro

Protein Sequence (250 amino acids)

>Ac3H11_4733 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-) (Acidovorax sp. GW101-3H11)
VVKGVNFVELRDAGDPVEIAARYNAQGADELTFLDITATSDGRDLILHIIEAVASQVFIP
LTVGGGVRTVEDVRRLLNAGADKTSFNSAAIANPDLINAVSAKYGAQCIVVAIDAKRRSA
EDALRIGANGQPVGEGWDVYSHGGRKNTGLDAIAWATEMARRGAGEILLTSMDRDGTKSG
FDLALTRAVSDAVSVPVIASGGVGNLDHLADGVQQGGADAVLAASIFHYGEYTVGQAKAR
MAERGIPVRL