Protein Info for Ac3H11_4583 in Acidovorax sp. GW101-3H11

Annotation: Heavy metal RND efflux outer membrane protein, CzcC family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 451 signal peptide" amino acids 1 to 40 (40 residues), see Phobius details PF02321: OEP" amino acids 66 to 240 (175 residues), 77.9 bits, see alignment E=4.6e-26 amino acids 272 to 439 (168 residues), 75 bits, see alignment E=3.5e-25

Best Hits

Swiss-Prot: 48% identical to CZCC_CUPMC: Cobalt-zinc-cadmium resistance protein CzcC (czcC) from Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)

KEGG orthology group: None (inferred from 99% identity to ajs:Ajs_1847)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LSS2 at UniProt or InterPro

Protein Sequence (451 amino acids)

>Ac3H11_4583 Heavy metal RND efflux outer membrane protein, CzcC family (Acidovorax sp. GW101-3H11)
MFKGTYLQEMPHAWRGGRKIKLAAGAAAIWLSASGGAFSQGLPPGPAVGERAPQSAAAAA
AEPLSLAKAIELALEGNPEVAAAKRQWEATEGQVLQGRSRPNPELAYSLEDTRSKTRTQS
WQLNLPVELGGKRAARTKAAEKTREQAQAQLAELQATVRANVAAAYFDVLTAQERLVLAR
DSAALAKSSTDTVSKRVAAGKVSPVEESKARVAEAGVRVELAQAASEQRNALSRLFALLG
QIDAPYTVLEGKAEKLPSVPSLADLQPLISSAPGVVLARIEVDRRKALTALEQSKRVPDV
TVSVGMQRSNETQRNVLLFGVSVPLPVFDRNQGNLLEALKLEDKARDELQAATVRLHSEV
AQARERLSTITAEVQSLQQEVLPGAKSAYDAATIGFENGKFNFLEVLDAQRTYFTAKSQY
LKALGEAHRAAADIDRLLGASMVPGLIATQH