Protein Info for Ac3H11_4581 in Acidovorax sp. GW101-3H11

Annotation: Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1047 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 332 to 348 (17 residues), see Phobius details amino acids 354 to 374 (21 residues), see Phobius details amino acids 380 to 399 (20 residues), see Phobius details amino acids 437 to 457 (21 residues), see Phobius details amino acids 466 to 493 (28 residues), see Phobius details amino acids 518 to 541 (24 residues), see Phobius details amino acids 868 to 887 (20 residues), see Phobius details amino acids 894 to 913 (20 residues), see Phobius details amino acids 919 to 944 (26 residues), see Phobius details amino acids 968 to 988 (21 residues), see Phobius details amino acids 997 to 1020 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1033 (1033 residues), 1724 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1024 (1024 residues), 1160 bits, see alignment E=0

Best Hits

Swiss-Prot: 78% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 99% identity to ajs:Ajs_1849)

MetaCyc: 71% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LPU5 at UniProt or InterPro

Protein Sequence (1047 amino acids)

>Ac3H11_4581 Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA (Acidovorax sp. GW101-3H11)
VLLAALGMAALGVISYQKLPIDAVPDITNVQVQINTQAAGYSPLETEQRVTYPIETVMAG
LPNLEQTRSLSRYGLSQVTVIFKDGTDIYFARQLVNERIQEARDKLPAGITPALGPISTG
LGEIYLWTVETKDGAKKPDGSPYTATDLREIQDWIIKPQLRNVPGVTEINSIGGFAKEYQ
IAPIPERLASLGVTLQDVVTALDRNNGNVGAGYIEKRGEQYLIRAPGQVKSLEDIGNVIL
SSANGVPVRVRDVAEVGIGRELRTGAATDNGREVVLGTVFMLIGENSRTVSQAVDKKMLE
VNKSLPEGVHAVTVYDRTVLVDKAISTVKKNLLEGAVLVIVILFLFLGNIRAAIITAMVI
PLSMLFTFTGMVQYKVSANLMSLGALDFGIIIDGAVVIVENCVRRLAHAQAHHGRPLTRA
ERFHEVFLASQESRRPLLFGQLIIMVVYLPIFALTGVEGKMFHPMAFTVVAALLGAMVLS
VTFIPAAVALFIGNRVSEKENFLLGHAKRLYGPLLDRVMAAKAVVLTAAAVAVILCGLIA
TRMGSEFVPNLNEGDFAIQALRIPGTSLSQSVQMQQQIERTLKEKFPEIERIFARTGTAE
IASDPMPPNISDGYIMLKPMAEWPEPRKTRDELLAAIQEVIGKIPGNNYEFSQPIQLRFN
ELISGVRSDVAVKIFGDDMDVLNKSAEEVSAMLQKIQGSSEVKVEQTTGLPMLTVNIDRQ
KAARYGLNVADIQDTVATAIGGREAGTMFEGDRRFDILVRLPESLRNDLEGMKRLPIPLP
RSANGTEAKTNFIPLGEVATFELAPGPNQVSRENGKRRIVVSTNVRGRDVGSFVAEAEKG
LAQIKIPTGYWTSWGGTFENLQSATQRLQIVVPVSLLLVFVLLFAMFGNVKDGLLVFTGI
PFALTGGILALWLRDIPMSISAAVGFIALSGVAVLNGLVMISYIRSLREGGVGLDEAIRD
GALTRLRPVLMTALVASLGFIPMAIATGTGAEVQRPLATVVIGGILSSTLLTLLVLPILY
RLAHRPDEEDEDVSAEPSHPPDVSASA