Protein Info for Ac3H11_4556 in Acidovorax sp. GW101-3H11

Annotation: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 51 to 398 (348 residues), 233.7 bits, E=3.3e-73
• PF13193: AMP-binding_C
  • amino acids 452 to 530 (79 residues), 82 bits, E=5e-27

Best Hits

KEGG orthology group: K08295, 2-aminobenzoate-CoA ligase [EC: 6.2.1.32] (inferred from 74% identity to pol:Bpro_0589)

Predicted SEED Role

"Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases"

MetaCyc Pathways

• anthranilate degradation II (aerobic) (2/2 steps found)
• anthranilate degradation III (anaerobic) (1/2 steps found)
• 4-hydroxy-2(1H)-quinolone biosynthesis (3/5 steps found)
• aurachin RE biosynthesis (1/5 steps found)
• superpathway of quinolone and alkylquinolone biosynthesis (3/10 steps found)
• 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis (1/8 steps found)
• aurachin A, B, C and D biosynthesis (3/11 steps found)
• anaerobic aromatic compound degradation (Thauera aromatica) (6/27 steps found)

KEGG Metabolic Maps

• Acridone alkaloid biosynthesis
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Carbazole degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.32

Sequence Analysis Tools

See A0A165LPA2 at UniProt or InterPro

Protein Sequence (553 amino acids)

>Ac3H11_4556 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases (Acidovorax sp. GW101-3H11)
MKAPSAQPDHFVHDRLPPPEAWPTLRYDLPELQIADQANLVQALFDQAERAGHSDRPLLR
GPHRTYTYRDARTEAARIAEVLTQDHGLVPGNRVLLRGGNTVEMALAWLGTVYAGLVAVA
TMPLLRAVELGSIIDRAQPTLALCDGRLLAELQAAQTQHPVLTTIVPFHTAPDAADLLQR
AQGKPGTTPPCPTSADDIALMAFTSGTTGAPKAAVHTHRDVLAGCEAWPRHVLKATPDDI
VAGSPPLAFTFGLGGLLVFPMWAGASVYFPDQPYTPETMVRLMREAGVTICYTAPTFYRQ
MAPFARQIGLPQLRTSVSAGEGLPDATRQLWREATGLDMTDGIGATEMFHIFISSAGGES
RAGAVGKVVPGYTAKVVDDDGHEVPRGTVGKLAVIGPTGCKYLDDPRQAKYVKDGWNYPG
DAFTQDADGYFFYQARDDDMIITAGYNVGGPEVEDALLRHPAVAECGVIGVPDEERGMVV
KAICVLKPGHTGDAAMVKTLQDHVKATIAPFKYPRVVEFVAALPRTETGKLQRFKLRQGA
GASPSHSPTKTTT