Protein Info for Ac3H11_452 in Acidovorax sp. GW101-3H11

Annotation: Polyphosphate kinase (EC 2.7.4.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 686 TIGR03705: polyphosphate kinase 1" amino acids 2 to 669 (668 residues), 856.6 bits, see alignment E=6.9e-262 PF13089: PP_kinase_N" amino acids 2 to 104 (103 residues), 96.9 bits, see alignment E=2.2e-31 PF02503: PP_kinase" amino acids 112 to 295 (184 residues), 196.3 bits, see alignment E=9.5e-62 PF17941: PP_kinase_C_1" amino acids 322 to 486 (165 residues), 227.7 bits, see alignment E=1.6e-71 PF13090: PP_kinase_C" amino acids 494 to 656 (163 residues), 180.8 bits, see alignment E=3.9e-57

Best Hits

Swiss-Prot: 50% identical to PPK1_PSEPK: Polyphosphate kinase (ppk) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K00937, polyphosphate kinase [EC: 2.7.4.1] (inferred from 88% identity to vei:Veis_1296)

Predicted SEED Role

"Polyphosphate kinase (EC 2.7.4.1)" in subsystem High affinity phosphate transporter and control of PHO regulon or Phosphate metabolism or Purine conversions (EC 2.7.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.4.1

Use Curated BLAST to search for 2.7.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LKC5 at UniProt or InterPro

Protein Sequence (686 amino acids)

>Ac3H11_452 Polyphosphate kinase (EC 2.7.4.1) (Acidovorax sp. GW101-3H11)
MFLDRDHSILAFNERVFDWAVRTDVPLLERLRYLCIVSSNLDEFFEVRAAPHITAAKKGE
TKGPYTVGSFEALSIKVHDLVERQYTLYNDALVPAFAQHGIRIVGHGDRSPEQRRWVHDY
FVREVRPLLIPVGLDPAHPFPQVANKSLNFIVRLKGHDAFGRENEIAIVKVPRALPRLIR
IPAKVAPSEALFVSLSSIIRAHLEDLFPGREVTEFSQFRVTRHSDLALDEEDVRNLRTAL
RQGLQHRHYGQAVRLEVSAGCSKFLSDFLLAQFGLPAAALYRVHGPVNLVRLTQLVDLVN
DPALLFPAWSSSWPRQLQPGVSIMDQLRQRDVLIHQPFESFDGLLAFLREAVNDPQVLVI
KQTIYRTGADSELMDLLSEAVRRGKEVMAVVELKARFDEEANINWAEALESIGAQVVYGV
VGLKTHAKMLLVTRREGRQLRRYGHLSTGNYNVRTARLYTDLSYLTADEETTADMDGVFN
HLASQNRPPKLRKLMLAPFHLHRRMIDKIEQVGQAASRGEDARIVAKMNALTDEALIRAL
ILAGQRGARIDLIVRGACMLAAQVPGITDNIRVRSVIGRFLEHTRVFYFRAGVEEDLYLS
SADWMNRNMMRRVELAWPITDPGLRQQIVDECLVAYLHDDRDAWTLNARGTYDRAPRPVD
GLGAQNALMVRYGPAAAISRVEQRTA